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Bile acid


DATA No : BBA0130 INFORMANT : Takashi Iida

NAME : 6-Oxo-5a-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H38O3 MOL.WT (average) : 374.557


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:162-164degC, (Me ester; mp, 85-87degC)(Ref. 0019/0237)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]d-20: -3.5pm3deg (C=0.6, dioxane)(Ref. 0074/0237)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:nmaxcm-1: 1710 (C=O)(Ref. 0019)

NMR SPECTRA:1H-NMR (CDCl3; 90MHz) d: 18-Me 0.69(s), 19-Me 0.72(s), 21-Me 0.94(d)(Ref. 0019)
Me ester 1H-NMR (CDCl3; 90MHz) d: 18-Me 0.66(s), 19-Me 0.73(s), 21-Me 0.93(d), COOMe 3.66(s)(Ref. 0019)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0019]
AUTHOR:Iida, T., Tamaru, T., Chang, F. C., Niwa, T., Goto, J., and Nambara, T.
TITLE:Potential bile acid metabolites. 20. A new synthetic route to stereoisomeric 3,6-dihydroxy- and 6-hydroxy-5 alpha-cholanoic acids PubMed ID:8212086
JOURNAL:Steroids.
VOL:58 PAGE : 362-369 (1993)
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[0074]
AUTHOR:Hoehn, W. M., Linsk, J., and Moffett, R. B.
TITLE:3-Keto-6(b)-hydroxycholanic Acid and 3(a)-Hydroxy-6-ketocholanic Acid.
JOURNAL:J. Am. Chem. Soc.
VOL:68 PAGE : 1855 -1857 (1946)
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[0237]
AUTHOR:Elliott, W. H. (1971) Allo Bile Acids, in The Bile Acids-Chemistry, Physiology, and Metabolism (Vol. 1: Chemistry) (Nair, P. P., and Kritchevsky, D. eds), pp47-93, Plenum Press, New York.
TITLE:
JOURNAL:
VOL: PAGE : - ()
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.