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Bile acid


DATA No : BBA0135 INFORMANT : Takashi Iida

NAME : 3,6-Dioxo-5a-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H36O4 MOL.WT (average) : 388.540


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:206-208degC, (Me ester; mp, 149-151.5degC)(Ref. 0066/0237)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]D: 0.0deg(Ref. 0001)
[a]d-22: +7.5deg (dioxane) (Me ester)(Ref. 0001/0237)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:Me ester 1H-NMR (CDCl3) d: 18-Me 0.70(s), 21-Me 0.94(d), 19-Me 0.96(s), COOMe 3.67(s)(Ref. 0004)

MASS SPECTRA:The spectrum (70eV) was shown as the Me ester derivative(Ref. 0007)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0001]
AUTHOR:Hill, R. A., Kirk, D. N., Makin, H. L. J., and Murphy, G. M. (1991) Chemical Data, Structures and Bibliographies, in Dictionary of Steroids, Chapman & Hall, London.
TITLE:
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[0004]
AUTHOR:Barnes, S., and Kirk, D. N. (1988) Nuclear Magnetic Resonance Spectroscopy of Bile Acids, in The Bile Acids-Chemistry, Physiology, and Metabolism (Vol. 4: Methods and Applications) (Setchell, K. D. R., Kritchevsky, D., and Nair, P. P. eds), pp65-136, Plenum Press, New York.
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[0007]
AUTHOR:Lawson, A. M., and Setchell, K. D. R. (1988) Mass Spectrometry of Bile Acids, in The Bile Acids-Chemistry, Physiology, and Metabolism (Vol. 4: Methods and Applications) (Setchall, K. D. R., Kritchevsky, D., and Nair, P. P. eds), pp 167-267, Plenum Press, New York.
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[0066]
AUTHOR:Ziegler, P.
TITLE:Substitution and Elimination Reactions During Acetolysis of Derivatives of 3b,6b-Dihydroxyallocholanic Acid.
JOURNAL:Can. J. Chem.
VOL:37 PAGE : 1004 -1007 (1959)
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[0237]
AUTHOR:Elliott, W. H. (1971) Allo Bile Acids, in The Bile Acids-Chemistry, Physiology, and Metabolism (Vol. 1: Chemistry) (Nair, P. P., and Kritchevsky, D. eds), pp47-93, Plenum Press, New York.
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JOURNAL:
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.