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Bile acid


DATA No : BBA0270 INFORMANT : Takashi Iida

NAME : 7-Oxo-5a-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H38O3 MOL.WT (average) : 374.557


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:82-84degC (Me ester)(Ref. 0041)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]d-25: -41.6pm0.5deg (C=1%, MeOH)(Ref. 0041)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:nmaxcm-1: 1739 (COOMe), 1712 (C=O), 1171 (COOMe)(Ref. 0041)

NMR SPECTRA:Me ester 1H-NMR (CDCl3; 90MHz) d: 18-Me 0.65(s), 19-Me 0.92(s), 21-Me 1.04(d)(Ref. 0008)
Me ester 13C-NMR (CDCl3; 22.53MHz) d: C-1 38.2, C-2 21.7, C-3 26.4, C-4 29.0, C-5 49.1, C-6 46.5, C-7 212.1, C-8 50.1, C-9 54.7, C-10 36.6, C-11 21.1, C-12 38.7, C-13 42.5, C-14 48.9, C-15 24.9, C-16 28.2, C-17 56.1, C-18 12.0, C-19 11.6, C-20 35.2, C-21 18.3, C-22 31.0, C-23 31.0, C-24 174.5, C-25 51.3(Ref. 0065)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0008]
AUTHOR:Iida, T., and Shinohara, T.
TITLE:Proton Nuclear Magnetic Resonance Spectra of Bile Acid Derivatives. Part2. Mono-, Di- and Trisubstituted Methyl 5a-Cholanoates.
JOURNAL:J. Coll. Engin. Nihon Univ. (A)
VOL:28 PAGE : 175 -179 (1987)
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[0041]
AUTHOR:Ziller, S. A., Jr., Doisy, E. A., Jr., and Elliott, W. H.
TITLE:Bile acids. XXV. Allochenodeoxycholic acid, a metabolite of 5 alpha-cholestan-3 beta-ol in the hyperthyroid rat PubMed ID:5715510
JOURNAL:J Biol Chem.
VOL:243 PAGE : 5280-5288 (1968)
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[0065]
AUTHOR:Momose, T., Iida, T., Tamura, T., and Matsumoto, T.
TITLE:13C-NMR Spectra of Oxo-bile Acid Methyl Esters.
JOURNAL:J. Jpn. Oil Chem. Soc. (Yukagaku)
VOL:36 PAGE : 954 -957 (1987)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.