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Bile acid


DATA No : BBA0347 INFORMANT : Mizuho Une

NAME : 5b-Cholestane-3a,7a,12a-triol

COMMON NAME:
SYMBOL:
FORMULA: C27H48O3 MOL.WT (average) : 420.668


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:186-187.5(Ref. 0374)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]D=+30.4 (Ref. 0380)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:m/z 546,456,366(base peak),253. (as TMS derivative) (Ref. 0375)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Patients with Cerebrotendinous xanthomatosis: Bile (Ref. 0375), urine (Ref. 0327)
CHEMICAL SYNTHESIS
(Ref. 0372/0374)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0327]
AUTHOR:Shimazu,K.,Kuwabara,M.,Yoshii,M.,Kihira,K.,Takeuchi,H.,Nakano,I.,Ozawa,S.,Hatta,Y,and Hoshita,T.
TITLE:Bile alcohol profiles in bile, urine, and feces of a patient with cerebrotendinous xanthomatosis. PubMed ID:3700361
JOURNAL:J.Biochem.
VOL:99 PAGE : 477 -483 (1986)
[TOP]

[0372]
AUTHOR:Shimizu,K.,Noda,F.,and Yamasaki,K.
TITLE:Preparation of 3a,7a,12a-trihydroxy-24a-oxocoprostane and 3a,7a,12a,24x-tetrahydroxycoprostane.
JOURNAL:J.Biochem.
VOL:45 PAGE : 625 -627 (1958)
[TOP]

[0374]
AUTHOR:Kazuno,T. and Mori,A.
TITLE:The synthesis of trihydroxycoprostane.
JOURNAL:Proc.Japan Acad.
VOL:30 PAGE : 486 -488 (1954)
[TOP]

[0375]
AUTHOR:Oftebro,H.,Bjorkhem,I.,Skrede,S.,Schreiner,A., and Pedersen, J.I.
TITLE:Cerebrotendinous xanthomatosis. A defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid. PubMed ID:7410549
JOURNAL:J.Clin.Invest.
VOL:65 PAGE : 1418 -1430 (1980)
[TOP]

[0380]
AUTHOR:Shefer,S.,Dayal,B.,Tint,G.S.,Salen,G., and Mosbach,E.H.
TITLE:Identification of pentahydroxy bile alcohols in cerebrotendinous xanthomatosis: characterization of 5b-cholestane-3a,7a,12a,24x,25-pentol and 5b-cholestane-3a,7a,12a,23x,25-pentol PubMed ID:1141769
JOURNAL:J.Lipid Res.
VOL:16 PAGE : 280 -286 (1975)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.