Lipopolysaccharide

DATA No : CLS0212 INFORMANT : Yoshio Kumazawa

NAME : 2'N-3""(hexadecanoyloxy)tetradecanoyl,3'N-3""(hexadecanoyloxy)tetradecanoyl, 2',3'-dideoxy b-(1

6) D-glucosyl 2N-3""hydroxytetradecanoyl,3-O-3""hydroxytetradecanoyl D-glucosamine 1,4'-bisphosphate

COMMON NAME	:
SYMBOL	:
FORMULA	:	C₁₀₀H₁₈₉O₂₄N₃P₂ MOL.WT (average) : 1879.524

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BIOLOGICAL ACTIVITY

Induce toxic lethality in galactosamine-sensitized mice
[Table 0002]
Pyrogenicity in rabbits
Tumor necrosis factor (TNF) secretion from mouse peritoneal macrophages
[Table 0003]
Inhibition of passive haemolysis
[Table 0004]

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT	:

BOILING POINT	:

REFRACTIVE INDEX	:

OPTICAL ROTATION	:

DENSITY	:

SOLUBILITY	:

SPECTRAL DATA

UV SPECTRA	:

IR SPECTRA	:

NMR SPECTRA	:

MASS SPECTRA	:	Laser desorption mass spectra of dephoshorylated free lipid A [Spectrum 0009] EI/MS of permethylated and N-acetylated disaccharides derivatives [Spectrum 0010]

OTHER SPECTRA	:

CHROMATOGRAM DATA

SOURCE

Campylobactor jejuni(Ref. 0212/0213)

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

Chemical composition of LPS of C. jejuni strains
[Table 0005]
Stractural analysis of the lipid A component of Campylobactor jejuni CCUG 10936 (serotype O:2)(Ref. 0213)

REFERENCES

[0212]

AUTHOR	:	Moran AP
TITLE	:	Biological and serological characterization of Campylobacter jejuni lipopolysaccharides with deviating core and lipid A structures. PubMed ID:7640672
JOURNAL	:	FEMS Immunol Med Microbiol
VOL	:	11 PAGE : 121 -130 (1995)

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[0213]

AUTHOR	:	Moran A.P, Zahringer U, Seydel U, Scholz D, Stut P, Rietschel ET
TITLE	:	Structural analysis of the lipid A component of Campylobacter jejuni CCUG 10936 (serotype O:2) lipopolysaccharide. Description of a lipid A containing a hybrid backbone of 2-amino-2-deoxy-D-glucose and 2,3- diamino-2,3-dideoxy-D-glucose. PubMed ID:2040305
JOURNAL	:	Eur J Biochem
VOL	:	198 PAGE : 459 -469 (1991)

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