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Lipopolysaccharide


DATA No : CLS0221 INFORMANT : Yoshio Kumazawa

NAME : 2'N-3''(nonadecanoyloxy)eicosanoyl, 3'-O-pentadecanoyl b-(1a_right6) D-glucosaminyl 2N-3''hydroxytetradecanoyl,3-O-3''hydroxyeicosanoyl D-glucosamine 4'-phosphate

COMMON NAME:
SYMBOL:
FORMULA: C100H190O19N2P MOL.WT (average) : 1755.554


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BIOLOGICAL ACTIVITY
Chlamydial LPS was less potent than Enterobacteriaceae LPS, as defined by its ability to activate mononuclear phagocytes and a Chinese hamster ovary cell line trancefected with the putative LPS receptor CD14(Ref. 0222)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:Positive-ion MALDI/TOF MS MALDI/IT MS, and LSIMS spectra
[Spectrum 0011]
High-energy CID spectrum of a quasi-molecular ion (MNa+) at 1794 atomic mass units
[Spectrum 0012]

OTHER SPECTRA:
CHROMATOGRAM DATA
Reverse-phase HPLC of the dimethyl-monophosphoryl lipid A
[Chromatogram 0002]
SOURCE
Chlamydia trachomatis(Ref. 0221)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE
Proposed fatty acyl distribution of dimethyl-monophosphoryl lipid A components
[Table 0006]
REFERENCES
[0221]
AUTHOR:Qureshi N, Kaltashov I, Walker K, Doroshenko V, Cotter RJ, Takayama K, Sievert TR, Rice PA, Lin JS, Golenbock DT
TITLE:Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. PubMed ID:9099706
JOURNAL:J Biol Chem
VOL:272 PAGE : 10594 -10600 (1997)
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[0222]
AUTHOR:Ingalls, R. R., Rice, P. A., Qureshi, N., Takayama, K., Lin, J. S., and Golenbock, D. T.
TITLE:The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated PubMed ID:7542638
JOURNAL:Infect Immun.
VOL:63 PAGE : 3125-3130 (1995)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.