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Lipopolysaccharide


DATA No : CLS0423 INFORMANT : Yoshio Kumazawa

NAME : 2'N-3''(dodecanoyloxy)tetradecanoyl, 3'-O-3''(tetradecanoyloxy)tetradecanoyl b-(1a_right6) D-glucosaminyl 2N-3''hydroxytetradecanoyl,3-O-3''hydroxytetradecanoyl D-glucosamine 1,4'-bisphosphate

COMMON NAME:
SYMBOL: bisphosphorylated disaccharide b-D-GlcpN-4-P-(1a_right6)-a-D-GlcpN-1-P
FORMULA: C94H176O25N2P2 MOL.WT (average) : 1796.349


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BIOLOGICAL ACTIVITY
Antibody obtained after immunization with the J-5 mutant of Escherichia coli O111 was suited to induce cross-reactive lipid A(Ref. 0425)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:13C-NMR spectrum of the hydrophilic backbone from lipid A
[Spectrum 0023]
1H,1H-COSY-NMR spectrum of the hydrophilic backbone from lipid A
[Spectrum 0024]
1H,13C-COSY-NMR spectrum of the hydrophilic backbone from lipid A
[Spectrum 0025]

MASS SPECTRA:Laser-desorption mass spectrum of dephosphorylated lipid A
[Spectrum 0026]

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Escherichia coli J-5(Ref. 0423)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE
1H-NMR data
[Table 0015]
13C-NMR data
[Table 0016]
REFERENCES
[0423]
AUTHOR:Holst, O., Muller-Loennies, S., Lindner, B., and Brade, H.
TITLE:Chemical structure of the lipid A of Escherichia coli J-5 PubMed ID:8319680
JOURNAL:Eur J Biochem.
VOL:214 PAGE : 695-701 (1993)
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[0425]
AUTHOR:Ziegler, E. J., Douglas, H., and Braude, A. I.
TITLE:Human antiserum for prevention of the local shwartzman reaction and death from bacterial lipopolysaccharides PubMed ID:4584346
JOURNAL:J Clin Invest.
VOL:52 PAGE : 3236-3238 (1973)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.