Lipopolysaccharide

DATA No : CLS2125 INFORMANT : Shoichi Kusumoto

NAME : 2-Deoxy-6-O-[2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-b-D-glucopyranosyl]-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-a-D-glucopyranose 1-Phosphate

COMMON NAME	:	Monophospholyl biosynthetic precursor of lipid A from Escherichia coli
SYMBOL	:	#405, LA-14-HP
FORMULA	:	C₆₈H₁₂₉N₂O₂₀P MOL.WT (average) : 1325.727

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BIOLOGICAL ACTIVITY

Re-LPs binding assay, IL-6-release, TNFa-release; (Ref. 2012)

PHYSICAL AND CHEMICAL PROPERTIES

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CHROMATOGRAM DATA

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CHEMICAL SYNTHESIS

(Ref. 2014)

METABOLISM

GENETIC INFORMATION

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REFERENCES

[2012]

AUTHOR	:	Kirikae, T., Schade, F. U., Zahringer, U., Kirikae, F., Brade, H., Kusumoto, S., Kusama, T., and Rietschel, E. T.
TITLE	:	The significance of the hydrophilic backbone and the hydrophobic fatty acid regions of lipid A for macrophage binding and cytokine induction PubMed ID:8156049
JOURNAL	:	FEMS Immunol Med Microbiol.
VOL	:	8 PAGE : 13-26 (1994)

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[2014]

AUTHOR	:	Imoto,M., Yoshimura,H., Yamamoto,M., Shimamoto,T., Kusumoto,S., and Shiba,T.
TITLE	:	Chemical Synthesis of phosphorylated tetraacyl disaccharide corresponding to a biosynthetic precursor lipid A.
JOURNAL	:	Tetrahedron Lett.
VOL	:	25 PAGE : 2667 -2670 (1984)

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