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Fatty acid


DATA No : DFA8105 INFORMANT : Tetsuyuki Kobayashi

NAME : 8S,15S-dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic acid

COMMON NAME:
SYMBOL: 8(S),15(S)-DiHETE
FORMULA: C20H32O4 MOL.WT (average) : 336.466


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BIOLOGICAL ACTIVITY
8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED 50 of 1.5 mM but is not chemotactic for neutrophils (Ref. 8133). 8(S),15(S)-diHETE exhibits hypoalgesic activity by antagonizing the hyperalgesic activity of 8(R),15(S)-diHETE and LTB 4 when measuring nociceptive activity in the rat hindpaw model of pain <<>8134>.
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SPECTRAL DATA
UV SPECTRA:lmax: 269 nm e: 40,000

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CHROMATOGRAM DATA

SOURCE
8(S),15(S)-DiHETE is formed when15(S)-HETE is subjected to further oxidation by 15-lipoxygenase (Ref. 8133).
CHEMICAL SYNTHESIS

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NOTE

REFERENCES
[8133]
AUTHOR:Morita, E., Schroder, J. M., and Christophers, E.
TITLE:Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid PubMed ID:2155268
JOURNAL:J Immunol.
VOL:144 PAGE : 1893-1900 (1990)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.