Fatty acid

DATA No : DFA8107 INFORMANT : Tetsuyuki Kobayashi

NAME : (

)8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid

COMMON NAME	:
SYMBOL	:	()8,9-DiHETrE
FORMULA	:	C₂₀H₃₄O₄ MOL.WT (average) : 338.482

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BIOLOGICAL ACTIVITY

Epoxide hydrolases convert the EpETrEs into vicinal diols(Ref. 8130), with the concurrent loss of much of their biological activity. The 8(S),9(R)-EpETrE isomer is metabolized by platelet cyclooxygenase to form 8(S),9(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor(Ref. 8135).

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REFERENCES

[8130]

AUTHOR	:	Oliw, E.H., Guengerich, F.P., and Oates, J.A.
TITLE	:	Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. PubMed ID:6801052
JOURNAL	:	J. Biol. Chem.
VOL	:	257 PAGE : 3771 -3781 (1982)

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[8135]

AUTHOR	:	Zhang, J. Y., Prakash, C., Yamashita, K., and Blair, I. A.
TITLE	:	Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase PubMed ID:1543485
JOURNAL	:	Biochem Biophys Res Commun.
VOL	:	183 PAGE : 138-143 (1992)

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