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Fatty acid


DATA No : DFA8110 INFORMANT : Tetsuyuki Kobayashi

NAME : (pm)5(6)-epoxy-8Z,11Z,14Z-eicosatrienoic acid

COMMON NAME:
SYMBOL: (pm)5(6)-EpETrE
FORMULA: C20H32O3 MOL.WT (average) : 320.466


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BIOLOGICAL ACTIVITY
In neuroendocrine cells such as the anterior pituitary and pancreatic islet, (pm)5(6)-EpETrE has been implicated in the mobilization of Ca 2+ and hormone secretion (Ref. 8138/8139).
PHYSICAL AND CHEMICAL PROPERTIES
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SPECTRAL DATA
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CHROMATOGRAM DATA

SOURCE
(pm)5(6)-EpETrE is biosynthesized in rat and rabbit liver microsomes by cytochrome P450 (Ref. 8130/8137).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[8130]
AUTHOR:Oliw, E.H., Guengerich, F.P., and Oates, J.A.
TITLE:Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. PubMed ID:6801052
JOURNAL:J. Biol. Chem.
VOL:257 PAGE : 3771 -3781 (1982)
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[8137]
AUTHOR:Chacos, N., Falck, J.R., Wixtrom, C., et al.
TITLE:Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. PubMed ID:6803794
JOURNAL:Biochem. Biophys. Res. Commun.
VOL:104 PAGE : 916 -922 (1982)
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[8138]
AUTHOR:Snyder, G., Lattanzio, F., Yadagiri, P., Falck, J. R., and Capdevila, J.
TITLE:5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells PubMed ID:3533073
JOURNAL:Biochem Biophys Res Commun.
VOL:139 PAGE : 1188-1194 (1986)
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[8139]
AUTHOR:Falck, J. R., Manna, S., Moltz, J., Chacos, N., and Capdevila, J.
TITLE:Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets PubMed ID:6411091
JOURNAL:Biochem Biophys Res Commun.
VOL:114 PAGE : 743-749 (1983)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.