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Fatty acid


DATA No : DFA8111 INFORMANT : Tetsuyuki Kobayashi

NAME : (pm)8(9)-epoxy-5Z,11Z,14Z-eicosatrienoic acid

COMMON NAME:
SYMBOL: (pm)8(9)-EpETrE
FORMULA: C20H32O3 MOL.WT (average) : 320.466


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BIOLOGICAL ACTIVITY
(pm)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction (Ref. 8140)>.(pm)8(9)-EpETrE has been shown to play a role in the recovery of depleted Ca2+ pools in cultured smooth muscle cells (Ref. 8141).
PHYSICAL AND CHEMICAL PROPERTIES
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CHROMATOGRAM DATA

SOURCE
(pm)8(9)-EpETrE is biosynthesized in rat and rabbit liver microsomes by cytochrome P450 (Ref. 8130/8137). (pm)8(9)-EpETrE is a major P450 metabolite in the renal cortex (Ref. 8135).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[8130]
AUTHOR:Oliw, E.H., Guengerich, F.P., and Oates, J.A.
TITLE:Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. PubMed ID:6801052
JOURNAL:J. Biol. Chem.
VOL:257 PAGE : 3771 -3781 (1982)
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[8135]
AUTHOR:Zhang, J. Y., Prakash, C., Yamashita, K., and Blair, I. A.
TITLE:Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase PubMed ID:1543485
JOURNAL:Biochem Biophys Res Commun.
VOL:183 PAGE : 138-143 (1992)
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[8137]
AUTHOR:Chacos, N., Falck, J.R., Wixtrom, C., et al.
TITLE:Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. PubMed ID:6803794
JOURNAL:Biochem. Biophys. Res. Commun.
VOL:104 PAGE : 916 -922 (1982)
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[8140]
AUTHOR:Katoh, T., Takahashi, K., Capdevila, J., Karara, A., Falck, J. R., Jacobson, H. R., and Badr, K. F.
TITLE:Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney PubMed ID:1928373
JOURNAL:Am J Physiol.
VOL:261 PAGE : F578-586 (1991)
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[8141]
AUTHOR:Graber, M. N., Alfonso, A., and Gill, D. L.
TITLE:Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid PubMed ID:9368016
JOURNAL:J Biol Chem.
VOL:272 PAGE : 29546-29553 (1997)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.