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Fatty acid


DATA No : DFA8126 INFORMANT : Tetsuyuki Kobayashi

NAME : 15S-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid

COMMON NAME:
SYMBOL: 15(S)-HEPE
FORMULA: C20H30O3 MOL.WT (average) : 318.450


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BIOLOGICAL ACTIVITY
15(S)-HEPE generated by soybean lipoxygenation of EPA inhibits RBL-1 cell 5-lipoxygenase with an IC50 of 28 mM(Ref. 8151).
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:lmax: 236nm e: 23,000

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
The biosynthesis of 15-HEPE from EPA in guinea pig epidermal enzyme preparations has been documented (Ref. 8151).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[8151]
AUTHOR:Miller, C., Yamaguchi, R. Y., and Ziboh, V. A.
TITLE:Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids PubMed ID:2559281
JOURNAL:Lipids.
VOL:24 PAGE : 998-1003 (1989)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.