Fatty acid

DATA No : DFA8138 INFORMANT : Tetsuyuki Kobayashi

NAME : 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid

COMMON NAME	:
SYMBOL	:	12(S)-HETE
FORMULA	:	C₂₀H₃₂O₃ MOL.WT (average) : 320.466

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BIOLOGICAL ACTIVITY

12(S)-HETE enhances tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin but not to type IV collagen at the concentration of 0.01mM to 0.1mM (Ref. 8171/8172).

PHYSICAL AND CHEMICAL PROPERTIES

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SPECTRAL DATA

UV SPECTRA	:	lmax: 237nm e: 27,000

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CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

12(S)-HETE is a metabolite of arachidonic acid via the 12-lipoxygenase pathway (Ref. 8170).

GENETIC INFORMATION

NOTE

REFERENCES

[8170]

AUTHOR	:	Hamberg, M. and Samuelsson, B.
TITLE	:	Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. PubMed ID:4215079
JOURNAL	:	Proc. Natl. Acad. Sci. USA
VOL	:	71 PAGE : 3400 -3404 (1974)

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[8171]

AUTHOR	:	Grossi, I. M., Fitzgerald, L. A., Umbarger, L. A., Nelson, K. K., Diglio, C. A., Taylor, J. D., and Honn, K. V.
TITLE	:	Bidirectionalcontrol of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid PubMed ID:2492204
JOURNAL	:	Cancer Res.
VOL	:	49 PAGE : 1029-1037 (1989)

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[8172]

AUTHOR	:	Honn, K. V., Nelson, K. K., Renaud, C., Bazaz, R., Diglio, C. A., and Timar, J.
TITLE	:	Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis PubMed ID:1470682
JOURNAL	:	Prostaglandins.
VOL	:	44 PAGE : 413-429 (1992)

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