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Fatty acid


DATA No : DFA8140 INFORMANT : Tetsuyuki Kobayashi

NAME : 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid

COMMON NAME:
SYMBOL: 15(S)-HETE
FORMULA: C20H32O3 MOL.WT (average) : 320.466


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BIOLOGICAL ACTIVITY
15(S)-HETE is a potent inflammatory mediator and agonist of tracheal mucus secretions (Ref. 8175). 15(S)-HETE also evokes contractions in a variety of blood vessels, and these responses are sensitive to thromboxane A2 receptor antagonists (Ref. 8176).
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:lmax: 236nm e: 27,000

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
15(S)-HETE is the metabolite of arachidonic acid from the 15-lipoxygenase pathway.
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[8175]
AUTHOR:Ramis, I., Rosello-Catafau, J., Bulbena, O., Picado, C., and Gelpi, E.
TITLE:15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric procedures PubMed ID:2613844
JOURNAL:J Chromatogr.
VOL:496 PAGE : 416-422 (1989)
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[8176]
AUTHOR:Van Diest, M. J., Verbeuren, T. J., and Herman, A. G.
TITLE:15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase PubMed ID:1824864
JOURNAL:J Pharmacol Exp Ther.
VOL:256 PAGE : 194-203 (1991)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.