Fatty acid

DATA No : DFA8141 INFORMANT : Tetsuyuki Kobayashi

NAME : 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

COMMON NAME	:
SYMBOL	:	20-HETE
FORMULA	:	C₂₀H₃₂O₃ MOL.WT (average) : 320.466

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BIOLOGICAL ACTIVITY

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CHEMICAL SYNTHESIS

METABOLISM

20-HETE is a cytochrome P metabolite of arachidonic acid (Ref. 8177). 20-HETE can be further metabolized to 20-hydroxy prostaglandin G2 and 20-hydroxy prostaglandin H2 (Ref. 8178).

GENETIC INFORMATION

NOTE

REFERENCES

[8177]

AUTHOR	:	Hatzelmann, A., and Ullrich, V.
TITLE	:	The omega-hydroxylation of arachidonic acid by human polymorphonuclear leukocytes PubMed ID:3129296
JOURNAL	:	Eur J Biochem.
VOL	:	173 PAGE : 445-452 (1988)

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[8178]

AUTHOR	:	Schwartzman, M. L., Falck, J. R., Yadagiri, P., and Escalante, B.
TITLE	:	Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites PubMed ID:2501294
JOURNAL	:	J Biol Chem.
VOL	:	264 PAGE : 11658-11662 (1989)

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