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Fatty acid


DATA No : DFA8141 INFORMANT : Tetsuyuki Kobayashi

NAME : 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

COMMON NAME:
SYMBOL: 20-HETE
FORMULA: C20H32O3 MOL.WT (average) : 320.466


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
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CHEMICAL SYNTHESIS

METABOLISM
20-HETE is a cytochrome P metabolite of arachidonic acid (Ref. 8177). 20-HETE can be further metabolized to 20-hydroxy prostaglandin G2 and 20-hydroxy prostaglandin H2 (Ref. 8178).
GENETIC INFORMATION

NOTE

REFERENCES
[8177]
AUTHOR:Hatzelmann, A., and Ullrich, V.
TITLE:The omega-hydroxylation of arachidonic acid by human polymorphonuclear leukocytes PubMed ID:3129296
JOURNAL:Eur J Biochem.
VOL:173 PAGE : 445-452 (1988)
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[8178]
AUTHOR:Schwartzman, M. L., Falck, J. R., Yadagiri, P., and Escalante, B.
TITLE:Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites PubMed ID:2501294
JOURNAL:J Biol Chem.
VOL:264 PAGE : 11658-11662 (1989)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.