Fatty acid

DATA No : DFA8153 INFORMANT : Tetsuyuki Kobayashi

NAME : 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid

COMMON NAME	:	lipoxin A₄
SYMBOL	:	LXA4
FORMULA	:	C₂₀H₃₂O₅ MOL.WT (average) : 352.465

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BIOLOGICAL ACTIVITY

LXA is equipotent to LTB in inducing superoxide generation in human neutrophils (0.1mM) (Ref. 8190). LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis promotion, natural killer cell inhibition, and monocyte migration and adhesion (Ref. 8190/8191/8192).

PHYSICAL AND CHEMICAL PROPERTIES

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SPECTRAL DATA

UV SPECTRA	:	lmax: 302nm e: 50,000

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CHROMATOGRAM DATA

SOURCE

LXA4 is formed in vitro by a number of mechanisms from arachidonic acid, 15-HpETE, and leukotriene A4 (LTA4 ) (Ref. 8189/8190).

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[8189]

AUTHOR	:	Edenius, C., Stenke, L., and Lindgren, J. A.
TITLE	:	On the mechanism of transcellular lipoxin formation in human platelets and granulocytes PubMed ID:1906402
JOURNAL	:	Eur J Biochem.
VOL	:	199 PAGE : 401-409 (1991)

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[8190]

AUTHOR	:	Serhan, C.N., Hamberg, M., Samuelsson, B.
TITLE	:	Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. PubMed ID:6089195
JOURNAL	:	Proc. Natl. Acad. Sci. USA
VOL	:	81 PAGE : 5335 -5339 (1984)

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[8191]

AUTHOR	:	Ramstedt, U., Serhan, C. N., Nicolaou, K. C., Webber, S. E., Wigzell, H., and Samuelsson, B.
TITLE	:	Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action PubMed ID:3782800
JOURNAL	:	J Immunol.
VOL	:	138 PAGE : 266-270 (1987)

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[8192]

AUTHOR	:	Maddox, J. F., and Serhan, C. N.
TITLE	:	Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction PubMed ID:8551217
JOURNAL	:	J Exp Med.
VOL	:	183 PAGE : 137-146 (1996)

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