Fatty acid

DATA No : DFA8157 INFORMANT : Tetsuyuki Kobayashi

NAME : 12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid

COMMON NAME	:
SYMBOL	:	12-OxoETE/12-KETE
FORMULA	:	C₂₀H₃₀O₃ MOL.WT (average) : 318.450

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BIOLOGICAL ACTIVITY

12-OxoETE induces a rapid, dose related increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence (Ref. 8200).

PHYSICAL AND CHEMICAL PROPERTIES

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SPECTRAL DATA

UV SPECTRA	:	lmax: 280nm e: 30,000

IR SPECTRA	:

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CHROMATOGRAM DATA

SOURCE

12-OxoETE is synthesized by human platelets and Aplaysia nervous tissue after incubation with arachidonic acid (Ref. 8197/8198). Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE (Ref. 8197/8199).

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[8197]

AUTHOR	:	Falgueyret, J. P., Leblanc, Y., and Riendeau, D.
TITLE	:	Stereoselective carbonyl reductases from rat skin and leukocyte microsomes converting 12-ketoeicosatetraenoic acid to 12(S)-HETE PubMed ID:2185947
JOURNAL	:	FEBS Lett.
VOL	:	262 PAGE : 197-200 (1990)

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[8198]

AUTHOR	:	Fruteau de Laclos, B., Maclouf, J., Poubelle, P., and Borgeat, P.
TITLE	:	Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acid PubMed ID:3107082
JOURNAL	:	Prostaglandins.
VOL	:	33 PAGE : 315-337 (1987)

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[8199]

AUTHOR	:	Falgueyret, J. P., Leblanc, Y., Rokach, J., and Riendeau, D.
TITLE	:	NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)- and 12(S)-hydroxyeicosatetraenoic acid by rat liver microsomes PubMed ID:3190686
JOURNAL	:	Biochem Biophys Res Commun.
VOL	:	156 PAGE : 1083-1089 (1988)

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[8200]

AUTHOR	:	Naccache, P. H., Leblanc, Y., Rokach, J., Patrignani, P., Fruteau de Laclos, B., and Borgeat, P.
TITLE	:	Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: evidence for the involvement of the leukotriene B4 receptor PubMed ID:1661162
JOURNAL	:	Biochim Biophys Acta.
VOL	:	1133 PAGE : 102-106 (1991)

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