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| COMMON NAME | : | 3-Ketodihydrosphingosine / 3-Ketosphinganine |
| SYMBOL | : | KDS |
| FORMULA | : | C18H37O2N1 MOL.WT (average) : 299.492 |
| BIOLOGICAL ACTIVITY |
| PHYSICAL AND CHEMICAL PROPERTIES |
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| SOLUBILITY | : | Insol. in water, soluble in CHCl3 and hot EtOH |
| SPECTRAL DATA |
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| CHROMATOGRAM DATA |
| SOURCE |
| CHEMICAL SYNTHESIS |
| METABOLISM |
| GENETIC INFORMATION |
| NOTE |
| REFERENCES |
| AUTHOR | : | Karlsson, K-A. |
| TITLE | : | On the Chemistry and Occurrence of Sphingolipid Long-Chain Bases. PubMed ID:4394487 |
| JOURNAL | : | Chem. Phys. Lipids |
| VOL | : | 5 PAGE : 6 -43 (1970) |
| AUTHOR | : | Merrill, A.H.Jr., and Sweeley, C.C. (1996) Sphingolipids:metabolism and cell signalling (Vance,D.E., and Vance,J.E., eds), pp309-339, Elsevier Science B.V., Amsterdam |
| TITLE | : | |
| JOURNAL | : | |
| VOL | : | PAGE : - () |
| AUTHOR | : | Hanada,K., Nishijima, M., and Akamatsu,Y. |
| TITLE | : | A Temperature-sensitive Mammalian Cell Mutant with Thermolabile Serine Palmitoyltransferase for the Sphingolipid Biosynthesis. PubMed ID:2125045 |
| JOURNAL | : | J. Biol. Chem. |
| VOL | : | 265 PAGE : 22137 -22142 (1990) |
| AUTHOR | : | Buede, R., Rinker-Schaffer,C., Pinto,W.J., Lester,R.L., and Dickson,R.C. |
| TITLE | : | Cloning and Characterization of LCB1,a Saccharomyces Gene Required for Biosynthesis of the Long-Chain Base Component of Sphingolipids. PubMed ID:2066332 |
| JOURNAL | : | J. Bacteriology |
| VOL | : | 173 PAGE : 4325 -4332 (1991) |
| AUTHOR | : | Nagiec, M.M., Baltisberger, J.A., Wells, G.B., Lester, R.L., and Dickson, R.C. |
| TITLE | : | The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. PubMed ID:8058731 |
| JOURNAL | : | Proc. Natl. Acad. Sci. USA |
| VOL | : | 91 PAGE : 7899 -7902 (1994) |
| AUTHOR | : | Zhao, C., Beeler, T., and Dunn, T. |
| TITLE | : | Suppressors of the Ca2+-sensitive Yeast Mutant(csg2) Identify Genes Involved in Sphingolipid Biosynthesis. PubMed ID:8063782 |
| JOURNAL | : | J. Biol. Chem. |
| VOL | : | 269 PAGE : 21480 -21488 (1994) |
| AUTHOR | : | Nagiec, M.M., Lester, R.L., and Dickson, R.C. |
| TITLE | : | Sphingolipid Synthesis: Identification and Characterization of Mammalian cDNAs Encoding the Lcb2 Subunit of Serine Palmitoyltransferase. PubMed ID:8921873 |
| JOURNAL | : | Gene |
| VOL | : | 177 PAGE : 237 -241 (1996) |
| AUTHOR | : | Hanada, K., Hara, T., Nishijima, M., Kuge, O., Dickson, R.C., and Nagiec, M.M. |
| TITLE | : | A Mammalian Homolog of the Yeast LCB1 Encodes a Component of Serine Palmitoyltransferase, the Enzyme Catalyzing the First Step in Sphingolipid Synthesis. PubMed ID:9405408 |
| JOURNAL | : | J. Biol. Chem. |
| VOL | : | 272 PAGE : 32108 -32114 (1997) |
| AUTHOR | : | Weiss, B., and Stoffel, W. |
| TITLE | : | Human and murine serine-palmitoyl-CoA transferase:Cloning expression and characterization of the key enzyme in sphingolipid synthesis. PubMed ID:9363775 |
| JOURNAL | : | Eur. J. Biochem. |
| VOL | : | 249 PAGE : 239 -247 (1997) |
| AUTHOR | : | Beeler, T., Bacikova, D., Gable, K., Hopkins, L., Johnson, C., Slife, H., and Dunn, T. |
| TITLE | : | The Saccharomyces cerevisiae TSC10/YBR265w Gene Encoding 3-Ketosphinganine Reductase Is Identified in a Screen for Temperature-sensitive Suppressors of the Ca2+-sensitive csg2D Mutant. PubMed ID:9804843 |
| JOURNAL | : | J. Biol. Chem. |
| VOL | : | 273 PAGE : 30688 -30694 (1998) |
| AUTHOR | : | Mendershausen, P.B., and Sweeley, C.C. |
| TITLE | : | Chemistry and metabolism of sphingolipids. Chemical synthesis of 2-amino-1-hydroxyoctadecan-3-one (3-Ketosphinganine). PubMed ID:4308002 |
| JOURNAL | : | Biochemistry |
| VOL | : | 8 PAGE : 2633 -2635 (1969) |