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Long chain alcohol


DATA No : DLL0008 INFORMANT : Yasushi Kawakami

NAME : 1-docosanol

COMMON NAME: Behenyl alcohol
SYMBOL:
FORMULA: C22H46O MOL.WT (average) : 326.600


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BIOLOGICAL ACTIVITY
This compound exerts a substantial inhibitory effect on replication of certain viruses. (Ref. 0074)(Ref. 0075)(Ref. 0076)(Ref. 0077)(Ref. 0078)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:Mp 70.8degC(Ref. 0061) Mp 80degC(Ref. 0073)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA
(Ref. 0073)
SOURCE

CHEMICAL SYNTHESIS
(Ref. 0061)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0061]
AUTHOR:F.,Francis,F.,J.,E.,CoLLins,S.,H.,Piper
TITLE:The n-Fatty Acids and Certain of their Derivatives
JOURNAL:Proc.R.Soc.London.A
VOL:158 PAGE : 691 -718 (1937)
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[0073]
AUTHOR:Joseph,Kalish
TITLE:62-ESSENTIAL OILS AND COSMETICS (108163g)
JOURNAL:CA
VOL:66 PAGE : 10123 -10123 (1967)
[TOP]

[0074]
AUTHOR:Katz, D. H., Marcelletti, J. F., Khalil, M. H., Pope, L. E., and Katz, L. R.
TITLE:Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex PubMed ID:1660151
JOURNAL:Proc Natl Acad Sci U S A.
VOL:88 PAGE : 10825-10829 (1991)
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[0075]
AUTHOR:Katz, D. H., Marcelletti, J. F., Pope, L. E., Khalil, M. H., Katz, L. R., and McFadden, R.
TITLE:n-docosanol: broad spectrum anti-viral activity against lipid-enveloped viruses PubMed ID:8030975
JOURNAL:Ann N Y Acad Sci.
VOL:724 PAGE : 472-488 (1994)
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[0076]
AUTHOR:Pope, L. E., Marcelletti, J. F., Katz, L. R., and Katz, D. H.
TITLE:Anti-herpes simplex virus activity of n-docosanol correlates with intracellular metabolic conversion of the drug PubMed ID:8906594
JOURNAL:J Lipid Res.
VOL:37 PAGE : 2167-2178 (1996)
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[0077]
AUTHOR:Marcelletti, J. F., Lusso, P., and Katz, D. H.
TITLE:n-Docosanol inhibits in vitro replication of HIV and other retroviruses PubMed ID:8825621
JOURNAL:AIDS Res Hum Retroviruses.
VOL:12 PAGE : 71-74 (1996)
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[0078]
AUTHOR:Habbema, L., De Boulle, K., Roders, G. A., and Katz, D. H.
TITLE:n-Docosanol 10% cream in the treatment of recurrent herpes labialis: a randomised, double-blind, placebo-controlled study PubMed ID:8982417
JOURNAL:Acta Derm Venereol.
VOL:76 PAGE : 479-481 (1996)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.