Glycosphingolipid
DATA No : GSG0075
INFORMANT : Ineo Ishizuka
NAME : Bis-sulfo-gangliotetraosylceramide
COMMON NAME | : | Bis-sulfo-gangliotetraosylceramide |
SYMBOL | : | SB1a |
FORMULA | : | MOL.WT (average) : |
Interaction with laminin, thrombospondin, and von willebrand factor (
Ref. 0044). Interaction with monoclonal antibodies 2H6G5 (IgM) and 4A9E10 (IgG3) (
Ref. 0083).
PHYSICAL AND CHEMICAL PROPERTIES |
MELTING POINT | : | |
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BOILING POINT | : | |
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REFRACTIVE INDEX | : | |
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OPTICAL ROTATION | : | |
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DENSITY | : | |
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SOLUBILITY | : | Behavior in the Folch partition (Ref. 0027). |
UV SPECTRA | : | |
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IR SPECTRA | : | |
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NMR SPECTRA | : | 1H-NMR in C/M 1:1 at 55 C: 4.46 ppm (J = 7.8 Hz), Gal (two doublets); 4.74 ppm (J = 7.4 Hz), GalNAc; in DMSO, 60 C: 4.51 ppm (J = 8.0), GalNAc; 4.32 ppm (J = 8.1), the terminal Gal; 4.33 ppm (J = 7.8), the internal Gal (Ref. 0081). |
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MASS SPECTRA | : | EI-MS (permethylated): m/z 222, 3-deuteriomethylated-2,4,6-trimethyl-Gal; m/z 187, 222-CD3OH (Ref. 0081/0033) SI-MS (Ref. 0036). Negative-mode LSIMS and CID (Ref. 0214).TLC-blotting/negative-ion LSIMS of mouse kidney SB1a [Spectrum 0001](I.Ishizuka) |
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OTHER SPECTRA | : | Absorption of the complex with Azure A,the abssorption of the acetates of sulfoglycolipids with Azure A (Ref. 0027). |
The long-chain base is predominantly t18:0 (
Ref. 0208)
[0027]
AUTHOR | : | Tadano-Aritomi,K., and Ishizuka,I. |
TITLE | : | Determination of peracetylated sulfoglycolipids using the azure A method. PubMed ID:6196425 |
JOURNAL | : | J. Lipid Res. |
VOL | : | 24 PAGE : 1368 -1375 (1983) |
[0033]
AUTHOR | : | Ishizuka, I., and Tadano-Aritomi, K. |
TITLE | : | Characterization of sulfoglycosphingolipids by direct probe electron impact mass spectrometry PubMed ID:6501265 |
JOURNAL | : | J Biochem (Tokyo). |
VOL | : | 96 PAGE : 829-839 (1984) |
[0036]
AUTHOR | : | Kushi, Y., Handa, S., and Ishizuka, I. |
TITLE | : | Secondary ion mass spectrometry for sulfoglycolipids: application of negative ion detection PubMed ID:4008462 |
JOURNAL | : | J Biochem (Tokyo). |
VOL | : | 97 PAGE : 419-428 (1985) |
[0044]
AUTHOR | : | Roberts, D. D., Rao, C. N., Liotta, L. A., Gralnick, H. R., and Ginsburg, V. |
TITLE | : | Comparison of the specificities of laminin, thrombospondin, and von Willebrand factor for binding to sulfated glycolipids PubMed ID:3486185 |
JOURNAL | : | J Biol Chem. |
VOL | : | 261 PAGE : 6872-6877 (1986) |
[0081]
AUTHOR | : | Tadano, K., Ishizuka, I., Matsuo, M., and Matsumoto, S. |
TITLE | : | Bis-sulfated gangliotetraosylceramide from rat kidney PubMed ID:7142156 |
JOURNAL | : | J Biol Chem. |
VOL | : | 257 PAGE : 13413-13420 (1982) |
[0083]
AUTHOR | : | Hiraiwa, N., Iida, N., Ishizuka, I., Itai, S., Shigeta, K., Kannagi, R., Fukuda, Y., and Imura, H. |
TITLE | : | Monoclonal antibodies directed to a disulfated glycosphingolipid, SB1a (GgOse4Cer-II3IV3-bis-sulfate), associated with human hepatocellular carcinoma PubMed ID:2846160 |
JOURNAL | : | Cancer Res. |
VOL | : | 48 PAGE : 6769-6774 (1988) |
[0208]
AUTHOR | : | Ishizuka, I. |
TITLE | : | Chemistry and functional distribution of sulfoglycolipids PubMed ID:9640458 |
JOURNAL | : | Prog Lipid Res. |
VOL | : | 36 PAGE : 245-319 (1997) |
[0214]
AUTHOR | : | Tadano-Aritomi, K., Kubo, H., Ireland, P., Okuda, M., Kasama, T., Handa, S., and Ishizuka, I. |
TITLE | : | Structural analysis of mono- and bis-sulfated glycosphingolipids by negative liquid secondary ion mass spectrometry with high- and low-energy collision-induced dissociation PubMed ID:7553669 |
JOURNAL | : | Carbohydr Res. |
VOL | : | 273 PAGE : 41-52 (1995) |
Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.