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Glycosphingolipid


DATA No : GSG1091 INFORMANT : Kazuo Nakamura

NAME : Galb1-3GalNAcb1-4(NeuAca2-3)Galb1-4GlcCer

COMMON NAME:
SYMBOL: GM1
FORMULA: MOL.WT (average) :


Download ChemDraw structure data
BIOLOGICAL ACTIVITY
Binding to: tetanus toxin (Ref. 1149), cholera toxin(Ref. 1150), botulinum toxin (Ref. 1151), interaction with hormones (FSH, LH, HCG) <<>>
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA: MALDI-TOFMS
[Spectrum 0001] (T.Taketomi) (Ref. 3072)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
peripheral nerve myelin(Ref. 1144), myelin(Ref. 1145), human leukemic polymorphonuclear leukocytes(Ref. 1146), synaps(Ref. 1147/1394) (Ref. 1094)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[1094]
AUTHOR:Kuhn
TITLE:
JOURNAL:Chem. Ber.
VOL:96 PAGE : 866 -880 (1963)
[TOP]

[1144]
AUTHOR:Fong, J. W., Ledeen, R. W., Kundu, S. K., and Brostoff, S. W.
TITLE:Gangliosides of peripheral nerve myelin PubMed ID:1255166
JOURNAL:J Neurochem.
VOL:26 PAGE : 157-162 (1976)
[TOP]

[1145]
AUTHOR:Suzuki, K., Poduslo, J. F., and Poduslo, S. E.
TITLE:Further evidence for a specific ganglioside fraction closely associated with myelin PubMed ID:4873454
JOURNAL:Biochim Biophys Acta.
VOL:152 PAGE : 576-586 (1968)
[TOP]

[1146]
AUTHOR:Dacremont, G., and Hildebrand, J.
TITLE:Characterization of two gangliosides from human leukemic polymorphonuclear leukocytes PubMed ID:1062221
JOURNAL:Biochim Biophys Acta.
VOL:424 PAGE : 315-322 (1976)
[TOP]

[1147]
AUTHOR:Naiki, M., Marcus, D.M., and Ledeen, R.
TITLE:Properties of antisera to ganglioside GM1 and asialo GM1 PubMed ID:4364954
JOURNAL:J Immunol.
VOL:113 PAGE : 84-93 (1974)
[TOP]

[1149]
AUTHOR:van Heyningen, S.
TITLE:Binding of ganglioside by the chains of tetanus toxin PubMed ID:964380
JOURNAL:FEBS Lett.
VOL:68 PAGE : 5-7 (1976)
[TOP]

[1150]
AUTHOR:Wiegandt, H., Ziegler, W., Staerk, J., Kranz, T., Ronneberger, H. J., Zilg, H., Karlsson, K. A., and Samuelsson, B. E.
TITLE:Studies of the ligand binding to cholera toxin, I. The lipophilic moiety of sialoglycolipids PubMed ID:1002130
JOURNAL:Hoppe Seylers Z Physiol Chem.
VOL:357 PAGE : 1637-1646 (1976)
[TOP]

[1151]
AUTHOR:Simpson, L. L., and Rapport, M. M.
TITLE:The binding of botulinum toxin to membrane lipids: sphingolipids, steroids and fatty acids PubMed ID:4936886
JOURNAL:J Neurochem.
VOL:18 PAGE : 1751-1759 (1971)
[TOP]

[1394]
AUTHOR:De Baecque, C., Johnson, A. B., Naiki, M., Schwarting, G., and Marcus, D. M.
TITLE:Ganglioside localization in cerebellar cortex: an immunoperoxidase study with antibody to GM1 ganglioside PubMed ID:963536
JOURNAL:Brain Res.
VOL:114 PAGE : 117-122 (1976)
[TOP]

[3072]
AUTHOR:Taketomi, T., Sugiyama, E.
TITLE:Extraction and Analysis of Multiple Sphingolipids from a Single Sample. PubMed ID:11070864
JOURNAL:Methods in Enzymology
VOL:312 PAGE : 80 -101 (2000)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.