Glycosphingolipid

DATA No : GSG1296 INFORMANT : Kazuo Nakamura

NAME : Fuca1-2Galb1-3GalNAcb1-4(NeuAca2-3)Galb1-4Glcb1-1Cer

COMMON NAME	:
SYMBOL	:	Fuc-GM1
FORMULA	:	MOL.WT (average) :

Download ChemDraw structure data

BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT	:

BOILING POINT	:

REFRACTIVE INDEX	:

OPTICAL ROTATION	:

DENSITY	:

SOLUBILITY	:

SPECTRAL DATA

UV SPECTRA	:

IR SPECTRA	:

NMR SPECTRA	:	400MHz 1D-H

MASS SPECTRA	:	Direct prove MS (Ref. 1097), GC/MS of PMAA (Ref. 1198), (-)FABMS(Ref. 1199), MALDI-TOFMS [Spectrum 0001] (T.Taketomi) Method (Ref. 3072)

OTHER SPECTRA	:

CHROMATOGRAM DATA

SOURCE

N-2-Acetylaminofluorene-fed Fischer rat liver(Ref. 1196), rat hepatoma HTC and H35 cells, rat liver and hepatocyte (Ref. 1197), Bovine thyroid (Ref. 1198), PC-12 phenochromocytoma cells (Ref. 1199) Bovine liver (Ref. 1095), brain (Ref. 1156); Boar testis (Ref. 1157), pig adipose tissue (Ref. 1158)

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

Fatty acids Normal acids less than 10% , 16:0(45%), 2-hydroxy acids more than 90% , 16h:0(42%)
24:0(23.4%), 24:1(20.7%) (Ref. 1199)

REFERENCES

[1095]

AUTHOR	:	Wiegandt, H.
TITLE	:	Gangliosides of extraneural organs. PubMed ID:4372157
JOURNAL	:	Hoppe-Seylers Zeitschrift Fur Physiologische Chemie
VOL	:	354 PAGE : 1049 -1056 (1973)

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[1097]

AUTHOR	:	Holms, E.H. and Hakomori, S.
TITLE	:	Isolation and characterization of a new fucoganglioside accumulated in precancerous rat liver and in rat hepatoma induced by N-2-acetylaminofluorene. PubMed ID:7085643
JOURNAL	:	J. Biol. Chem.
VOL	:	257 PAGE : 7698 -7703 (1982)

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[1156]

AUTHOR	:	Ghidoni, R., Sonnino, S., Tettamanti, G., Wiegandt, H., and Zambotti, V.
TITLE	:	On the structure of two new gangliosides from beef brain PubMed ID:965992
JOURNAL	:	J Neurochem.
VOL	:	27 PAGE : 511-515 (1976)

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[1157]

AUTHOR	:	Suzuki, A., Ishizuka, I., and Yamakawa, T.
TITLE	:	Isolation and characterization of a ganglioside containing fucose from boar testis PubMed ID:1213997
JOURNAL	:	J Biochem (Tokyo).
VOL	:	78 PAGE : 947-954 (1975)

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[1158]

AUTHOR	:	Ohashi, M., and Yamakawa, T.
TITLE	:	Isolation and characterization of glycosphingolipids in pig adipose tissue. PubMed ID:893369
JOURNAL	:	J. Biochem.
VOL	:	81 PAGE : 1675 -1690 (1977)

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[1196]

AUTHOR	:	Holmes EH. Hakomori S.
TITLE	:	Isolation and characterization of a new fucoganglioside accumulated in precancerous rat liver and in rat hepatoma induced by N-2-acetylaminofluorene. PubMed ID:7085643
JOURNAL	:	J. Biolo Chem.
VOL	:	257 PAGE : 7698 -7703 (1982)

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[1197]

AUTHOR	:	Baumann, H., Nudelman, E., Watanabe, K., and Hakomori, S.
TITLE	:	Neutral fucolipids and fucogangliosides of rat hepatoma HTC and H35 cells, rat liver, and hepatocytes PubMed ID:445466
JOURNAL	:	Cancer Res.
VOL	:	39 PAGE : 2637-2643 (1979)

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[1198]

AUTHOR	:	Macher, B. A., Pacuszka, T., Mullin, B. R., Sweeley, C. C., Brady, R. O., and Fishman, P. H.
TITLE	:	Isolation and identification of a fucose-containing ganglioside from bovine thyroid gland PubMed ID:497244
JOURNAL	:	Biochim Biophys Acta.
VOL	:	588 PAGE : 35-43 (1979)

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[1199]

AUTHOR	:	Ariga, T., Kobayashi, K., Kuroda, Y., Yu, R. K., Suzuki, M., Kitagawa, H., Inagaki, F., and Miyatake, T.
TITLE	:	Characterization of tumor-associated fucogangliosides from PC 12 pheochromocytoma cells PubMed ID:3654655
JOURNAL	:	J Biol Chem.
VOL	:	262 PAGE : 14146-14153 (1987)

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[3072]

AUTHOR	:	Taketomi, T., Sugiyama, E.
TITLE	:	Extraction and Analysis of Multiple Sphingolipids from a Single Sample. PubMed ID:11070864
JOURNAL	:	Methods in Enzymology
VOL	:	312 PAGE : 80 -101 (2000)

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