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Isoprenoid


DATA No : IIP0004 INFORMANT : Yoshichika Yoshioka

NAME : [2E]-3,7-Dimethyl-2,6-octadien-1-ol

COMMON NAME: Geraniol
SYMBOL: GOH
FORMULA: C10H18O MOL.WT (average) : 154.249


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
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SPECTRAL DATA
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NMR SPECTRA:The 2H-labeled geraniol gave rise to 2H NMR powder patterns interpretable in terms of quadrupole splittings and splin-lattice relaxation times. Spin-lattice relaxation time measurements revealed high rates of motion for geraniol relative to cholesterol in similar membrane hosts and revealed correlation times close to the fatty acyl methyl termini in phosphatidylcholine.(Ref. 0038)

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CHEMICAL SYNTHESIS

METABOLISM
The product derived from geranyl diphosphate. The potential for feedback inhibition by isoprene intermediates in the isoprene biosynthetic pathway was investigated. The relative inhibitory capasity were as follows: GG-PP > F-PP > G-PP > FOH > dol-P. GOH and dolichol were not inhibitors(Ref. 0039).
GENETIC INFORMATION

NOTE

REFERENCES
[0038]
AUTHOR:de Ropp, J. S., and Troy, F. A.
TITLE:2H NMR investigation of the organization and dynamics of polyisoprenols in membranes PubMed ID:4066690
JOURNAL:J Biol Chem.
VOL:260 PAGE : 15669-15674 (1985)
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[0039]
AUTHOR:Hinson, D. D., Chambliss, K. L., Toth, M. J., Tanaka, R. D., and Gibson, K. M.
TITLE:Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways PubMed ID:9392419
JOURNAL:J Lipid Res.
VOL:38 PAGE : 2216-2223 (1997)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.