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Isoprenoid


DATA No : IIP0008 INFORMANT : Yoshichika Yoshioka

NAME : [2E,6E,10E]-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol

COMMON NAME: Geranylgeraniol
SYMBOL: GGOH
FORMULA: C20H34O MOL.WT (average) : 290.483


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BIOLOGICAL ACTIVITY
Geranylgeraniol had a potent apoptosis-inducing activity in HL-60 cells.(Ref. 0040) Geranylgeraniol causes a decrease in levels of calreticulin and tyrosine phosphorylation of a 36-kDa protein prior to the appearance of apoptotic features in HL-60 cells.(Ref. 0041) Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells.(Ref. 0042)
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CHEMICAL SYNTHESIS

METABOLISM
The product derived from geranylgeranyl diphosphate.
GENETIC INFORMATION

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REFERENCES
[0040]
AUTHOR:Ohizumi, H., Masuda, Y., Nakajo, S., Sakai, I., Ohsawa, S., and Nakaya, K.
TITLE:Geranylgeraniol is a potent inducer of apoptosis in tumor cells PubMed ID:7775375
JOURNAL:J Biochem (Tokyo).
VOL:117 PAGE : 11-13 (1995)
[TOP]

[0041]
AUTHOR:Nakajo, S., Okamoto, M., Masuda, Y., Sakai, I., Ohsawa, S., and Nakaya, K.
TITLE:Geranylgeraniol causes a decrease in levels of calreticulin and tyrosine phosphorylation of a 36-kDa protein prior to the appearance of apoptotic features in HL-60 cells PubMed ID:8831684
JOURNAL:Biochem Biophys Res Commun.
VOL:226 PAGE : 741-745 (1996)
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[0042]
AUTHOR:Masuda, Y., Nakaya, M., Nakajo, S., and Nakaya, K.
TITLE:Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells PubMed ID:9175767
JOURNAL:Biochem Biophys Res Commun.
VOL:234 PAGE : 641-645 (1997)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.