Isoprenoid

DATA No : IIP0040 INFORMANT : Yoshichika Yoshioka

NAME : [6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54E,58E]-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63-Hexadecamethyl-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62-tetrahexacontapentadecaen-1-ol

COMMON NAME	:	Dolichol-16, a-Dihydrohexadecaprenol
SYMBOL	:	Dol-16
FORMULA	:	C₈₀H₁₃₂O MOL.WT (average) : 1109.903

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BIOLOGICAL ACTIVITY

The biological role of dolichol (review)(Ref. 0043).

PHYSICAL AND CHEMICAL PROPERTIES

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CHROMATOGRAM DATA

Separation of dolichol from dehydrodolichol by a simple two-plate thin-layer chromatography(Ref. 0052).

SOURCE

The compound was found as prenol in Schizosaccharomyces pombe(Ref. 0028). Dolichol content in different regions of the rat brain (cerebral cortex, striatum, hippocampus, cerebellum, and brain stem) were analyzed from birth to the age of 2 years. The level of dolichol increased almost 100-fold during the first 10 months of life and continued to increase thereafter(Ref. 0058).

CHEMICAL SYNTHESIS

METABOLISM

Incorporation of tritium from tritiated water into dolichol in the kidneys and liver of mice as a function of age(Ref. 0066). Age-associated changes in dolichol metabolism in the kidneys and liver of mice(Ref. 0066). Dolichol contents of various organs of mice used as a model for Niemann-Pick's type C disease (liver, spleen, kidney, brain, testis, lung, adipose tissue, heart, intestine, skeletal muscle). Contents in subfractions isolated from the liver of mice used as a model for NPC (mitocondria, lysosomes, microsomes)(Ref. 0071). The potential for feedback inhibition by isoprene intermediates in the isoprene biosynthetic pathway was investigated. The relative inhibitory capasity were as follows: GG-PP > F-PP > G-PP > FOH > dol-P. GOH and dolichol were not inhibitors(Ref. 0039).

GENETIC INFORMATION

NOTE

REFERENCES

[0028]

AUTHOR	:	Quellhorst, G. J., Jr., Piotrowski, J. S., Steffen, S. E., and Krag, S. S.
TITLE	:	Identification of Schizosaccharomyces pombe prenol as dolichol-16,17 PubMed ID:9514857
JOURNAL	:	Biochem Biophys Res Commun.
VOL	:	244 PAGE : 546-550 (1998)

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[0039]

AUTHOR	:	Hinson, D. D., Chambliss, K. L., Toth, M. J., Tanaka, R. D., and Gibson, K. M.
TITLE	:	Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways PubMed ID:9392419
JOURNAL	:	J Lipid Res.
VOL	:	38 PAGE : 2216-2223 (1997)

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[0043]

AUTHOR	:	Chojnacki, T., and Dallner, G.
TITLE	:	The biological role of dolichol PubMed ID:3291859
JOURNAL	:	Biochem J.
VOL	:	251 PAGE : 1-9 (1988)

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[0052]

AUTHOR	:	Sagami, H., Kurisaki, A., Ogura, K., and Chojnacki, T.
TITLE	:	Separation of dolichol from dehydrodolichol by a simple two-plate thin-layer chromatography PubMed ID:1479294
JOURNAL	:	J Lipid Res.
VOL	:	33 PAGE : 1857-1861 (1992)

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[0058]

AUTHOR	:	Zhang, Y., Appelkvist, E. L., Kristensson, K., and Dallner, G.
TITLE	:	The lipid compositions of different regions of rat brain during development and aging PubMed ID:9363798
JOURNAL	:	Neurobiol Aging.
VOL	:	17 PAGE : 869-875 (1996)

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[0066]

AUTHOR	:	Crick, D. C., and Rip, J. W.
TITLE	:	Age-associated changes in dolichol and dolichyl phosphate metabolism in the kidneys and liver of mice PubMed ID:2752016
JOURNAL	:	Biochim Biophys Acta.
VOL	:	1004 PAGE : 180-186 (1989)

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[0071]

AUTHOR	:	Schedin, S., Pentchev, P. G., Brunk, U., and Dallner, G.
TITLE	:	Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease PubMed ID:7616223
JOURNAL	:	J Neurochem.
VOL	:	65 PAGE : 670-676 (1995)

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