Isoprenoid
DATA No : IIP0057
INFORMANT : Yoshichika Yoshioka
NAME : [6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54Z,58Z,62Z,66Z,70Z,74Z,78E,82E]-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79,83,87-Docosamethyl-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78,82,86-octaoctacontahenicosaen-1-ol
| COMMON NAME | : | Dolichol-22, a-Dihydrodocosaprenol |
| SYMBOL | : | Dol-22 |
| FORMULA | : | C110H180O MOL.WT (average) : 1518.606 |
The biological role of dolichol (review)(
Ref. 0043). Extraction of microsomes with n-heptane and subsequent reincorporation of dolichol were done in order to investigate the influence of dolichol on microsomal membrane functions. Dolichol affected microsomal membrane fluidity, but did not modify the activities of certain microsome membrane enzymes(
Ref. 0062). HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Geranylgeranylpyrophosphate and mevalonate completely reversed the effect of the inhibitors, while farnesylpyrophosphate partially reversed it and dolichol had no effect(
Ref. 0064).
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Human tissues (testes, adrenal, liver, thyroid, pancreas, prostate, heart, kidney, spleen, lung)(
Ref. 0054). Human tissues (liver, testis, spleen, pituitary)(
Ref. 0048). Rat and human tissues (spleen, liver, kidney, myocardium, lung, pancreas, adrenal)(
Ref. 0051). The effects of dietary proteins on the accumulation of dolichol in kidney, spleen, brain, and heart were studied. There were increases in dolichol contents in rat tissues with age. The contents of kidney and spleen were influenced by the diet(
Ref. 0057). Dolichol content in different regions of the rat brain (cerebral cortex, striatum, hippocampus, cerebellum, and brain stem) were analyzed from birth to the age of 2 years. The level of dolichol increased almost 100-fold during the first 10 months of life and continued to increase thereafter(
Ref. 0058).
Rat liver hyperplastic nodules(
Ref. 0048). Human liver cirrosis and hepatocarcinoma (
Ref. 0048). Age-related chnges of dolichyl phosphate content in rat and human tissues (spleen, liver, kidney, heart, lung, pancreas, adrenal)(
Ref. 0051). Dolichol contents of various organs of mice used as a model for Niemann-Pick's type C disease (liver, spleen, kidney, brain, testis, lung, adipose tissue, heart, intestine, skeletal muscle). Contents in subfractions isolated from the liver of mice used as a model for NPC (mitocondria, lysosomes, microsomes)(
Ref. 0071).
[0043]
| AUTHOR | : | Chojnacki, T., and Dallner, G. |
| TITLE | : | The biological role of dolichol PubMed ID:3291859 |
| JOURNAL | : | Biochem J. |
| VOL | : | 251 PAGE : 1-9 (1988) |
[0048]
| AUTHOR | : | Eggens, I., Chojnacki, T., Kenne, L., and Dallner, G. |
| TITLE | : | Separation, quantitation and distribution of dolichol and dolichyl phosphate in rat and human tissues PubMed ID:6849949 |
| JOURNAL | : | Biochim Biophys Acta. |
| VOL | : | 751 PAGE : 355-368 (1983) |
[0051]
| AUTHOR | : | Kalen, A., Appelkvist, E. L., and Dallner, G. |
| TITLE | : | Age-related changes in the lipid compositions of rat and human tissues PubMed ID:2779364 |
| JOURNAL | : | Lipids. |
| VOL | : | 24 PAGE : 579-584 (1989) |
[0054]
| AUTHOR | : | Rupar, C. A., and Carroll, K. K. |
| TITLE | : | Occurrence of dolichol in human tissues PubMed ID:661513 |
| JOURNAL | : | Lipids. |
| VOL | : | 13 PAGE : 291-293 (1978) |
[0057]
| AUTHOR | : | Ishinaga, M. |
| TITLE | : | Effects of aging and diet on the accumulation of dolichol in rat tissues PubMed ID:9213436 |
| JOURNAL | : | Biochem Cell Biol. |
| VOL | : | 74 PAGE : 265-270 (1996) |
[0058]
| AUTHOR | : | Zhang, Y., Appelkvist, E. L., Kristensson, K., and Dallner, G. |
| TITLE | : | The lipid compositions of different regions of rat brain during development and aging PubMed ID:9363798 |
| JOURNAL | : | Neurobiol Aging. |
| VOL | : | 17 PAGE : 869-875 (1996) |
[0062]
| AUTHOR | : | Aberg, F., Jakobsson-Borin, A., Olsson, M., Brunk, U., and Dallner, G. |
| TITLE | : | Influence of dolichol on microsomal membrane functions PubMed ID:8832099 |
| JOURNAL | : | Cell Mol Biol (Noisy-le-grand). |
| VOL | : | 42 PAGE : 683-690 (1996) |
[0064]
| AUTHOR | : | Iimura, O., Vrtovsnik, F., Terzi, F., and Friedlander, G. |
| TITLE | : | HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture PubMed ID:9328935 |
| JOURNAL | : | Kidney Int. |
| VOL | : | 52 PAGE : 962-972 (1997) |
[0071]
| AUTHOR | : | Schedin, S., Pentchev, P. G., Brunk, U., and Dallner, G. |
| TITLE | : | Changes in the levels of dolichol and dolichyl phosphate in a murine model of Niemann-Pick's type C disease PubMed ID:7616223 |
| JOURNAL | : | J Neurochem. |
| VOL | : | 65 PAGE : 670-676 (1995) |
Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.
