Isoprenoid

DATA No : IIP0058 INFORMANT : Yoshichika Yoshioka

NAME : [6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54Z,58Z,62Z,66Z,70Z,74Z,78Z,82E,86E]-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79,83,87,91-Tricosamethyl-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78,82,86,90-dononacontadocosaen-1-ol

COMMON NAME	:	Dolichol-23, a-Dihydrotricosaprenol
SYMBOL	:	Dol-23
FORMULA	:	C₁₁₅H₁₈₈O MOL.WT (average) : 1586.723

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BIOLOGICAL ACTIVITY

The biological role of dolichol (review)(Ref. 0043). HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Geranylgeranylpyrophosphate and mevalonate completely reversed the effect of the inhibitors, while farnesylpyrophosphate partially reversed it and dolichol had no effect(Ref. 0064).

PHYSICAL AND CHEMICAL PROPERTIES

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SPECTRAL DATA

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NMR SPECTRA	:	1H-NMR spectrum at 100MHz (with spectrum)(Ref. 0048).

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CHROMATOGRAM DATA

SOURCE

Bovine pituitary glands(Ref. 0048).

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[0043]

AUTHOR	:	Chojnacki, T., and Dallner, G.
TITLE	:	The biological role of dolichol PubMed ID:3291859
JOURNAL	:	Biochem J.
VOL	:	251 PAGE : 1-9 (1988)

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[0048]

AUTHOR	:	Eggens, I., Chojnacki, T., Kenne, L., and Dallner, G.
TITLE	:	Separation, quantitation and distribution of dolichol and dolichyl phosphate in rat and human tissues PubMed ID:6849949
JOURNAL	:	Biochim Biophys Acta.
VOL	:	751 PAGE : 355-368 (1983)

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[0064]

AUTHOR	:	Iimura, O., Vrtovsnik, F., Terzi, F., and Friedlander, G.
TITLE	:	HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture PubMed ID:9328935
JOURNAL	:	Kidney Int.
VOL	:	52 PAGE : 962-972 (1997)

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