Isoprenoid

DATA No : IIP0059 INFORMANT : Yoshichika Yoshioka

NAME : [6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54Z,58Z,62Z,66Z,70Z,74Z,78Z,82Z,86E,90E]-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75,79,83,87,91,95-Tetracosamethyl-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70,74,78,82,86,90,94-hexanonacontatricosaen-1-ol

COMMON NAME	:	Dolichol-24, a-Dihydrotetracosaprenol
SYMBOL	:	Dol-24
FORMULA	:	C₁₂₀H₁₉₆O MOL.WT (average) : 1654.840

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BIOLOGICAL ACTIVITY

HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Geranylgeranylpyrophosphate and mevalonate completely reversed the effect of the inhibitors, while farnesylpyrophosphate partially reversed it and dolichol had no effect(Ref. 0064).

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NOTE

The effect of dolichols, polyprenols, dolichol esterified with fatty acids, and dolichyl phosphate on the structure and fluidity of model membranes was studied using 31P NMR, small-angle x-ray scattering, differential scanning calorimetry, and freeze-fracture electron microscopy. Dolichol and dolichol derivatives destabilize unsaturated phosphatidylethanolamine containing bilayer structures and promote hexagonal II phase formation. Dolichol and dolichyl-P increase the fatty acid fluidity in phosphatidylethanolamine mixtures(Ref. 0044).

REFERENCES

[0044]

AUTHOR	:	Valtersson, C., van Duyn, G., Verkleij, A. J., Chojnacki, T., de Kruijff, B., and Dallner, G.
TITLE	:	The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes PubMed ID:3919007
JOURNAL	:	J Biol Chem.
VOL	:	260 PAGE : 2742-2751 (1985)

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[0064]

AUTHOR	:	Iimura, O., Vrtovsnik, F., Terzi, F., and Friedlander, G.
TITLE	:	HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture PubMed ID:9328935
JOURNAL	:	Kidney Int.
VOL	:	52 PAGE : 962-972 (1997)

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