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Isoprenoid


DATA No : IIP0073 INFORMANT : Yoshichika Yoshioka

NAME : [6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54Z,58E,62E]-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67-Heptadecamethyl-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66-octahexacontahexadecaen-1-yl diphosphate

COMMON NAME: Dolichyl-17 diphosphate, a-Dihydroheptadecaprenyl diphosphate
SYMBOL: Dol-17-PP
FORMULA: C85H142O7P2 MOL.WT (average) : 1337.980


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BIOLOGICAL ACTIVITY
Calf brain microsomes catalyze the enzymatic release of P from exogenous Dol-PP by a bacitracin-sensitive reaction(Ref. 0102). Metabolic labeling of rat liver slices with mevalonic acid revealed the accumulation of E,E,E-geranylgeranyl (di)phosphate as well as dolichyl (di)phosphate (C85 and C90) and dehydrodolichol (C85 and C90), but no accumulation of Z,E,E-geranylgeranyl (di)phosphate or E,E-farnesyl (di)phosphate was detected(Ref. 0026).
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CHEMICAL SYNTHESIS

METABOLISM
The effects of TSH on dolichol-linked sugar pools and oligosaccharyltransferase activity in thyroid cells were investigated. TSH slightly increased the amount of dolichol-PP and acitivated the oligosaccharyltransferase(Ref. 0072).
GENETIC INFORMATION

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REFERENCES
[0026]
AUTHOR:Sagami, H., Matsuoka, S., and Ogura, K.
TITLE:Formation of Z,E,E-geranylgeranyl diphosphate by rat liver microsomes PubMed ID:1995610
JOURNAL:J Biol Chem.
VOL:266 PAGE : 3458-3463 (1991)
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[0072]
AUTHOR:Desruisseau, S., Valette, A., Franc, J. L., and Chabaud, O.
TITLE:Thyrotropin controls dolichol-linked sugar pools and oligosaccharyltransferase activity in thyroid cells PubMed ID:8902853
JOURNAL:Mol Cell Endocrinol.
VOL:122 PAGE : 223-228 (1996)
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[0102]
AUTHOR:Scher, M. G., and Waechter, C. J.
TITLE:Brain dolichyl pyrophosphate phosphatase. Solubilization, characterization, and differentiation from dolichyl monophosphate phosphatase activity PubMed ID:6094565
JOURNAL:J Biol Chem.
VOL:259 PAGE : 14580-14585 (1984)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.