Isoprenoid

DATA No : IIP0074 INFORMANT : Yoshichika Yoshioka

NAME : [6Z,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z,42Z,46Z,50Z,54Z,58Z,62E,66E]-3,7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71-Octadecamethyl-6,10,14,18,22,26,30,34,38,42,46,50,54,58,62,66,70-doheptacontaheptadecaen-1-yl diphosphate

COMMON NAME	:	Dolichyl-18 diphosphate, a-Dihydrooctadecaprenyl diphosphate
SYMBOL	:	Dol-18-PP
FORMULA	:	C₉₀H₁₅₀O₇P₂ MOL.WT (average) : 1406.097

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BIOLOGICAL ACTIVITY

Metabolic labeling of rat liver slices with mevalonic acid revealed the accumulation of E,E,E-geranylgeranyl (di)phosphate as well as dolichyl (di)phosphate (C85 and C90) and dehydrodolichol (C85 and C90), but no accumulation of Z,E,E-geranylgeranyl (di)phosphate or E,E-farnesyl (di)phosphate was detected(Ref. 0026).

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CHEMICAL SYNTHESIS

METABOLISM

The effects of TSH on dolichol-linked sugar pools and oligosaccharyltransferase activity in thyroid cells were investigated. TSH slightly increased the amount of dolichol-PP and acitivated the oligosaccharyltransferase(Ref. 0072).

GENETIC INFORMATION

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REFERENCES

[0026]

AUTHOR	:	Sagami, H., Matsuoka, S., and Ogura, K.
TITLE	:	Formation of Z,E,E-geranylgeranyl diphosphate by rat liver microsomes PubMed ID:1995610
JOURNAL	:	J Biol Chem.
VOL	:	266 PAGE : 3458-3463 (1991)

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[0072]

AUTHOR	:	Desruisseau, S., Valette, A., Franc, J. L., and Chabaud, O.
TITLE	:	Thyrotropin controls dolichol-linked sugar pools and oligosaccharyltransferase activity in thyroid cells PubMed ID:8902853
JOURNAL	:	Mol Cell Endocrinol.
VOL	:	122 PAGE : 223-228 (1996)

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