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Sphingophospholipid


DATA No : PSP6004 INFORMANT : Takehiko Yokomizo

NAME : 4-hydroxy-D-erythro-sphinganine-1-phosphate

COMMON NAME: phytosphingosine -1-phosphate
SYMBOL: PHS-1-P
FORMULA: C18H40NO6P MOL.WT (average) : 397.487


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BIOLOGICAL ACTIVITY
A potential modulator of cellular processes (Ref. 6020). Stimulate proliferation and resistance to stress in yeast (Ref. 6021/6022).
PHYSICAL AND CHEMICAL PROPERTIES
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SOLUBILITY:It is difficult to suspend phytosphingosine-1-phosphate using organic solvents so typically it is suspended in methanol to aliquot, the methanol dried and the residue dispersed using fatty acid free BSA solution. The solubility of stock solutions may be increased by the addition of dimethylamine.
SPECTRAL DATA
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CHEMICAL SYNTHESIS

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GENETIC INFORMATION

NOTE

REFERENCES
[6020]
AUTHOR:Li, S., Wilson, W. K., and Schroepfer, G. J., Jr.
TITLE:Chemical synthesis of D-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes PubMed ID:9869657
JOURNAL:J Lipid Res.
VOL:40 PAGE : 117-125 (1999)
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[6021]
AUTHOR:Skrzypek, M. S., Nagiec, M. M., Lester, R. L., and Dickson, R. C.
TITLE:Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces PubMed ID:9973338
JOURNAL:J Bacteriol.
VOL:181 PAGE : 1134-1140 (1999)
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[6022]
AUTHOR:Dickson, R. C., and Lester, R. L.
TITLE:Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae PubMed ID:10366774
JOURNAL:Biochim Biophys Acta.
VOL:1438 PAGE : 305-321 (1999)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.