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Sphingophospholipid


DATA No : PSP6005 INFORMANT : Takehiko Yokomizo

NAME : D-erythro-C8 ceramide-1-phosphate

COMMON NAME: C8 Ceramide-1-phosphate
SYMBOL: C8 ceramide-1-P
FORMULA: C26H52NO6P MOL.WT (average) : 505.668


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BIOLOGICAL ACTIVITY
Stimulates DNA synthesis when added exogenously to cultured fibroblasts (Ref. 6023). Mitogenic activity is antagonized by cell permeable ceramides (Ref. 6023).
PHYSICAL AND CHEMICAL PROPERTIES
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SOLUBILITY:Soluble in DMSO and ethanol.
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REFERENCES
[6023]
AUTHOR:Gomez-Munoz, A., Duffy, P. A., Martin, A., O'Brien, L., Byun, H. S., Bittman, R., and Brindley, D. N.
TITLE:Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides PubMed ID:7746276
JOURNAL:Mol Pharmacol.
VOL:47 PAGE : 833-839 (1995)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.