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COMMON NAME | : | b-Estradiol / Cis-estradiol / Estradiol / 3,17-Epidihydroxyestratriene / Dihydrofollicular hormone / Dihydrofolliculin / Dihydroxyestrin / Dihydrotheelin / Compudose 365 / Dihydromenformon / Dimenformon / Diogyn / Estrovite / Femestral / Gynergon / Gynoestryl / Lamdiol / Macrodiol / Oestergon / Ovahormon / Ovasterol / Ovocyclin / Ovocylin / Perlatanol / Primofol / Profoliol / Progynon-dh |
SYMBOL | : | |
FORMULA | : | C18H24O2 MOL.WT (average) : 272.382 |
BIOLOGICAL ACTIVITY |
PHYSICAL AND CHEMICAL PROPERTIES |
MELTING POINT | : | 173-179![]() |
BOILING POINT | : | |
REFRACTIVE INDEX | : | |
OPTICAL ROTATION | : | [a]25/D= from +76 to +83![]() |
DENSITY | : | |
SOLUBILITY | : | Hardly sol in water. Sol in organic solvents like alcohol, acetone, dioxane. Slightly sol in vegetable oil. (Ref. 0104) |
SPECTRAL DATA |
UV SPECTRA | : | max. 225, 280nm (Ref. 0104) |
IR SPECTRA | : | |
NMR SPECTRA | : | |
MASS SPECTRA | : | |
OTHER SPECTRA | : | e=2,120 (281nm), E1%/1cm=78 (Ref. 0105) |
CHROMATOGRAM DATA |
SOURCE |
CHEMICAL SYNTHESIS |
METABOLISM |
GENETIC INFORMATION |
NOTE |
REFERENCES |
AUTHOR | : | Maccorquodale,D.W., Thayer,S.A., and Doisy,E.A. |
TITLE | : | The Isolation of the Principal Estrogenic Substance of Liquor Folliculi. |
JOURNAL | : | J.Biol.Chem. |
VOL | : | 115 PAGE : 435 -448 (1936) |
AUTHOR | : | Monographs in the Merck Index an encyclopedia of chemicals, drugs, and biologicals (Budavari,S., O'Neil,M.J., Smith,A., and Heckelman,P.E.,eds. 1989), pp583-583, MERCK & CO., Inc. Rahway, N.J. |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Sober,H.A., (1968) Section F Steroids in Handbook of Biochemistery Selected Data for Molecular Biology (Sober,H.A., eds.) ppF11-F11, The Chemical Rubber, Cleveland |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Eder,U., Gibian,H., Haffer,G., Neef,G., Sauer,G., and Wiechert,R. |
TITLE | : | Total Synthesis of Optically Active Steroids, XIV Synthesis of Estradiol. |
JOURNAL | : | Chem.Ber. |
VOL | : | 109 PAGE : 2948 -2953 (1976) |
AUTHOR | : | Oppolzer,W., and Roberts,D.A. |
TITLE | : | The Enantioselective Synthesis of (+)-Estradiol From 1,3-Dihydrobenzo-[c] Thiophene-2,2-Dioxide by Successive Thermal SO2-Extrusion and Cycloaddition Reactions. |
JOURNAL | : | Helv.Chim.Acta |
VOL | : | 63 PAGE : 1703 -1705 (1980) |