|
| COMMON NAME | : | b-Estradiol / (+)-Estradiol |
| SYMBOL | : | |
| FORMULA | : | C18H24O2 MOL.WT (average) : 272.382 |
| BIOLOGICAL ACTIVITY |
| PHYSICAL AND CHEMICAL PROPERTIES |
| MELTING POINT | : | 173-179 C. (Ref. 0378/0106) |
| BOILING POINT | : | |
| REFRACTIVE INDEX | : | |
| OPTICAL ROTATION | : | [a]25/D=+76 to +83 (dioxane). (Ref. 0378/0106) |
| DENSITY | : | |
| SOLUBILITY | : | Almost insol in water. Freely sol in alcohol, acetone, dioxane, other organic solvents. Sparingly sol in vegetable oils. (Ref. 0378/0106) |
| SPECTRAL DATA |
| UV SPECTRA | : | UVmax: 225, 280 nm (Ref. 0379) |
| IR SPECTRA | : | |
| NMR SPECTRA | : | |
| MASS SPECTRA | : | |
| OTHER SPECTRA | : | |
| CHROMATOGRAM DATA |
| SOURCE |
| CHEMICAL SYNTHESIS |
| METABOLISM |
| GENETIC INFORMATION |
| NOTE |
| REFERENCES |
| AUTHOR | : | Maccorquodale,D.W., Thayer,S.A., and Doisy,E.A. |
| TITLE | : | The Isolation of the Principal Estrogenic Substance of Liquor Folliculi. |
| JOURNAL | : | J.Biol.Chem. |
| VOL | : | 115 PAGE : 435 -448 (1936) |
| AUTHOR | : | Eder,U., Gibian,H., Haffer,G., Neef,G., Sauer,G., and Wiechert,R. |
| TITLE | : | Total Synthesis of Optically Active Steroids, XIV Synthesis of Estradiol. |
| JOURNAL | : | Chem.Ber. |
| VOL | : | 109 PAGE : 2948 -2953 (1976) |
| AUTHOR | : | Oppolzer,W., and Roberts,D.A. |
| TITLE | : | The Enantioselective Synthesis of (+)-Estradiol From 1,3-Dihydrobenzo-[c] Thiophene-2,2-Dioxide by Successive Thermal SO2-Extrusion and Cycloaddition Reactions. |
| JOURNAL | : | Helv.Chim.Acta |
| VOL | : | 63 PAGE : 1703 -1705 (1980) |
| AUTHOR | : | Butenandt,A.,and Goergens,C. |
| TITLE | : | Über a- und b- Oestradiol. |
| JOURNAL | : | Z. Physiol. Chem. |
| VOL | : | 248 PAGE : 129 -141 (1937) |
| AUTHOR | : | Inhoffen,H.H.,and Zühlsdorff,G. |
| TITLE | : | Übergang von Sterinen in aromatische Verbindungen, V. Mitteil.: Aromatisierung des Ringes A durch Methylwanderung. |
| JOURNAL | : | Ber. |
| VOL | : | 74 PAGE : 604 -617 (1941) |
| AUTHOR | : | Florey,K. (1975) Estradiol valerate, in Analytical profiles of drug substances 4 (Florey,K., eds.) pp192-208, Academic Press, New York |
| TITLE | : | |
| JOURNAL | : | |
| VOL | : | PAGE : - () |