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Steroid


DATA No : SST0068 INFORMANT : Hideaki Nishino

NAME : 19-Nor-17a-pregna-1,3,5(10)-trien-20-yne-3,17-diol / 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol

COMMON NAME: Ethinyl estradiol
SYMBOL:
FORMULA: C20H24O2 MOL.WT (average) : 296.403


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BIOLOGICAL ACTIVITY
Preparation from estrone. (Ref. 0391)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:145-146degC (Ref. 0391)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]/D=+1deg (in dioxan) (Ref. 0391)

DENSITY:

SOLUBILITY:Insol in water. Sol in the proportion of 1: 6 ethanol, 4 ehter, 5 acetone, 4 dioxane, 20 chloroform. Sol in vegetable oils, fixed alkalihydroxides solution. (Ref. 0391)
SPECTRAL DATA
UV SPECTRA:UVmax (ethanol): 281nm (e=2040pm60) (Ref. 0392)

IR SPECTRA:

NMR SPECTRA:NMR spectra. (Ref. 0392)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM
Estrogenic activity (application to hormonotherapy for human and animals). (Ref. 0391)
GENETIC INFORMATION

NOTE
Properties (Ref. 0392)
REFERENCES
[0391]
AUTHOR:Inhoffen,H.H.,Logemann,W.,Hohlweg,W.,and Serini,A.
TITLE:Untersuchungen in der Sexualhormon-Reihe.
JOURNAL:Ber.
VOL:71 PAGE : 1024 -1032 (1938)
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[0392]
AUTHOR:Hampel,B.,and Krä;mer,M.
TITLE:Die Kernresonanzspektren von Steroiden in Polaren Lösungsmitteln. 1. Dimemthylsulfoxid (DMS).
JOURNAL:Ber.
VOL:98 PAGE : 3255 -3263 (1965)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.