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Steroid


DATA No : SST0186 INFORMANT : Hideaki Nishino

NAME : 21-Hydroxypregn-4-ene-3,20-dione / 4-Pregnen-21-ol-3,20-dione

COMMON NAME: Deoxyxorticosterone / 21-Hydroxyprogesterone / Desoxycorticosterone / 11-Deoxycorticosterone / Cortexone / Desoxycortone / Kendall's Desoxy Compound B / Reichstein's Substance Q
SYMBOL:
FORMULA: C21H30O3 MOL.WT (average) : 330.461


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BIOLOGICAL ACTIVITY
Preparation of D4-3-keto-21-acetoxy-pregnen-20-on. (Ref. 0615) Preparation from pregnen-(4)-ol-(20)-on-(3)-al-(21). (Ref. 0735)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:141-142degC (ether). (Ref. 0615/0188)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]22/D=+178deg (c=1.5 in alcohol). (Ref. 0188)

DENSITY:

SOLUBILITY:Sol in alcohol, acetone. (Ref. 0188)
SPECTRAL DATA
UV SPECTRA:UVmax 240nm (loge=Ca, 4). (Ref. 0615)

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Animals. Adrenal glands. (Ref. 0615) Isolation from water beetle, Dytiscus marginalis. (Ref. 0736)
CHEMICAL SYNTHESIS

METABOLISM
Action as an adrenocortical steroid (Salt-regulating). (Ref. 0615)
GENETIC INFORMATION

NOTE

REFERENCES
[0188]
AUTHOR:Steiger,M., and Reichstein,T.
TITLE:Desoxy-cortico-steron (21-Oxy-progesteron) aus D5-3-Oxy-ätio-cholensäure (XII. Mitteilung Über Bestandteile der Nebennieren-Rinde)
JOURNAL:Helv.Chim.Acta
VOL:20 PAGE : 1164 -1179 (1937)
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[0615]
AUTHOR:Reichstein,T.,and von Euw,J.
TITLE:Über Bestandteile der Nebennierenrinde. (20. Mitteilung). Isolierung der Substanzen Q (Desoxy-corticosteron) und R sowie weiterer Stoffe.
JOURNAL:Helv. Chim. Acta
VOL:21 PAGE : 1197 -1210 (1938)
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[0735]
AUTHOR:Schindler,W.,Frey,H.,and Reichstein,T.
TITLE:Über Bestandteile der Nebennierenrinde und verwandte. 45. Mitteilung. Pregnen-(4)-ol-(20)-on-(3)-al-(21).
JOURNAL:Helv. Chim. Acta
VOL:24 PAGE : 360 -374 (1941)
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[0736]
AUTHOR:Schildknecht,H.,Siewerdt,R.,and Maschwitz,U.
TITLE:Ein Wirbeltierhormon als Wehrstoff des Gelbrandkäfers (Dytiscus marginalis).
JOURNAL:Angew. Chem.
VOL:78 PAGE : 392 -392 (1966)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.