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Steroid


DATA No : SST9020 INFORMANT : Etsuko Yasugi

NAME : 5b-cholestane-3a,7a,12a-triol

COMMON NAME:
SYMBOL:
FORMULA: C27H48O3 MOL.WT (average) : 420.668


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:186-187.5degC (Ref. 9022)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:+30.4deg (Ref. 9024)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:m/e= 546,456,366(base peak),253 (TMS deriv.) (Ref. 9023)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
cerebrotendinous xanthomatosis patient bile (Ref. 9023),urine (Ref. 9007)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[9007]
AUTHOR:Shimazu,K., Kuwabara,M., Yoshii,M., Kihira,K., Takeuchi,H., Nakano,I., Ozawa,S., Onuki,M., Hatta,Y., and Hoshita,T.
TITLE:Bile Alcohol Profiles in Bile, Urine, and Feces of a Patients with Cerebrotendinous Xanthomatosis. PubMed ID:3700361
JOURNAL:J. Biochem.
VOL:99 PAGE : 477 -483 (1986)
[TOP]

[9022]
AUTHOR:Kazuno,T., and Mori,A.
TITLE:The Synthesis of Trihydroxycoprostane
JOURNAL:Proc. Japan Acad.
VOL:30 PAGE : 486 -488 (1954)
[TOP]

[9023]
AUTHOR:Oftebro,H., Bjorkhem,I., Skrede,S., Schreiner,A., and Pedersen,J.I.
TITLE:Cerebrotendinous Xanthomatosis a Defect in Mitochondrial 26-Hydroxylation Required For Normal Biosynthesis of Cholic Acid. PubMed ID:7410549
JOURNAL:J. Clin. Invest.
VOL:65 PAGE : 1418 -1430 (1980)
[TOP]

[9024]
AUTHOR:Shefer,S., Dayal,B., Tint,G.S., Salen,G., and Mosbach,E.H.
TITLE:Identification of Pentahydroxy Bile Alcohols in Cerebrotendinous Xanthomatosis: Characterization of 5b-Cholestane-3a,7a,12a,24,25-Pentol and 5b-Cholestane-3a,7a,12a,23,25-Pentol. PubMed ID:1141769
JOURNAL:J. Lipid Res.
VOL:16 PAGE : 280 -286 (1975)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.