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COMMON NAME | : | |
SYMBOL | : | apo C-II |
FORMULA | : | MOL.WT (average) : |
BIOLOGICAL ACTIVITY |
PHYSICAL AND CHEMICAL PROPERTIES |
MELTING POINT | : | Molecular weight:8,837 Isoelectric point:4.9(Ref. 4401) |
BOILING POINT | : | The number of amino acid residues :79 |
REFRACTIVE INDEX | : | Amino acid sequences:Further investigations are required. |
OPTICAL ROTATION | : | Structure:The primary structure of apo C-II is comprised of single-stranded polypeptides. Amphiphilic helix structures are observed in segments 13-22, 28-38, and 43-51. Hydrophobic peptides in segments 66-78, 60-78, 55-78, and 50-78 do not bind to phospholipids, while the segment 43-49 is highly hydrophobic and has a helix structure, thus being involved in lipid binding. |
DENSITY | : | Amino acid compositions (Ref. 4408) |
SOLUBILITY | : | (Ref. 4402) |
SPECTRAL DATA |
UV SPECTRA | : | |
IR SPECTRA | : | |
NMR SPECTRA | : | |
MASS SPECTRA | : | |
OTHER SPECTRA | : | |
CHROMATOGRAM DATA |
SOURCE |
CHEMICAL SYNTHESIS |
METABOLISM |
GENETIC INFORMATION |
NOTE |
REFERENCES |
AUTHOR | : | Sharpe, C. R., Sidoli, A., Shelley, C. S., Lucero, M. A., Shoulders, C. C., and Baralle, F. E. |
TITLE | : | Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance PubMed ID:6328445 |
JOURNAL | : | Nucleic Acids Res. |
VOL | : | 12 PAGE : 3917-3932 (1984) |
AUTHOR | : | Sparrow, J. T., and Gotto, A. M., Jr. |
TITLE | : | Phospholipid binding studies with synthetic apolipoprotein fragments PubMed ID:6772077 |
JOURNAL | : | Ann N Y Acad Sci. |
VOL | : | 348 PAGE : 187-211 (1980) |
AUTHOR | : | Brown, W. V., Levy, R. I., and Fredrickson, D. S. |
TITLE | : | Studies of the proteins in human plasma very low density lipoproteins PubMed ID:4981584 |
JOURNAL | : | J Biol Chem. |
VOL | : | 244 PAGE : 5687-5694 (1969) |
AUTHOR | : | LaRosa, J. C., Levy, R. I., Herbert, P., Lux, S. E., and Fredrickson, D. S. |
TITLE | : | A specific apoprotein activator for lipoprotein lipase PubMed ID:5459123 |
JOURNAL | : | Biochem Biophys Res Commun. |
VOL | : | 41 PAGE : 57-62 (1970) |
AUTHOR | : | Eisenberg, S., and Rachmilewitz, D. |
TITLE | : | Interaction of rat plasma very low density lipoprotein with lipoprotein lipase-rich (postheparin) plasma PubMed ID:170350 |
JOURNAL | : | J Lipid Res. |
VOL | : | 16 PAGE : 341-351 (1975) |
AUTHOR | : | Wu, A. L., and Windmueller, H. G. |
TITLE | : | Identification of circulating apolipoproteins synthesized by rat small intestine in vivo PubMed ID:632283 |
JOURNAL | : | J Biol Chem. |
VOL | : | 253 PAGE : 2525-2528 (1978) |
AUTHOR | : | Yamamura, T., Sudo, H., Ishikawa, K., and Yamamoto, A. |
TITLE | : | Familial type I hyperlipoproteinemia caused by apolipoprotein C-II deficiency PubMed ID:227429 |
JOURNAL | : | Atherosclerosis. |
VOL | : | 34 PAGE : 53-65 (1979) |
AUTHOR | : | Jackson,R.L., and Holdsworth,G.(1986) Isolation and Characterization of Apolipoproteins C-I, C-II, C-III, in Methods in ENZYMOLOGY Vol.128 (Segrest J.P., and Albers J.J., eds), pp223-246, Academic Press, Inc. |
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