![]() |
COMMON NAME | : | 13-cis-retinoic acid,Isotretinoin |
SYMBOL | : | |
FORMULA | : | C20H28O2 MOL.WT (average) : 300.435 |
BIOLOGICAL ACTIVITY |
PHYSICAL AND CHEMICAL PROPERTIES |
MELTING POINT | : | 174-175![]() |
BOILING POINT | : | |
REFRACTIVE INDEX | : | |
OPTICAL ROTATION | : | |
DENSITY | : | |
SOLUBILITY | : |
SPECTRAL DATA |
UV SPECTRA | : | lmax=354 nm(E1%1cm 1,325 in ethanol)(Ref. 0013) |
IR SPECTRA | : | |
NMR SPECTRA | : | 1H-NMR(d,CDCl3,220MHz):1.03(6H,1-Me),~1.46(2H,2-CH2),~1.63(2H,3-CH2),1.72(3H,5-Me),2.00(3H,9-Me),~2.0(2H,4-Me),2.10(3H,13-Me),5.69(1H,14-H),6.17(1H,J=16.0Hz,8-H),6.29(1H,J=11.5Hz,10-H),6.29(1H,J=16.0Hz,7-H),7.03 (1H,J=11.5,15.0Hz,11-H),7. 77(1H,J=15.0Hz,12-H),~9.9(1H,COOH)(Ref. 0003) 13C-NMR(d,CDCl3,22.63MHz):12.9,19.4,21.1,21.6,29.0,29.0,33.3,34.4,40.0,115.9,128.9,129.4,130.1,130.3,132.9,137.4,137.9,140.3,153.3,171.4(CO)(Ref. 0004) |
MASS SPECTRA | : | |
OTHER SPECTRA | : | |
CHROMATOGRAM DATA |
SOURCE |
CHEMICAL SYNTHESIS |
METABOLISM |
GENETIC INFORMATION |
NOTE |
REFERENCES |
AUTHOR | : | Michael B. Sporn, Anita B. Roberts, DeWitt S. Goodman,The Retinoids Biology,Chemistry, and Medicine Second Edition, pp229-256, Raven Press, New York |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Schwieter, U., Englert, G., Rigassi, N., and Vetter, W. |
TITLE | : | Physical organic methods in carotenoid research PubMed ID:5377333 |
JOURNAL | : | Pure Appl Chem. |
VOL | : | 20 PAGE : 365-420 (1969) |
AUTHOR | : | Englert, G. |
TITLE | : | A 13C-NMR. Study of cis-trans isomeric vitamins A, carotenoids and related compounds PubMed ID:1194053 |
JOURNAL | : | Helv Chim Acta. |
VOL | : | 58 PAGE : 2367-2390 (1975) |
AUTHOR | : | Tsukita kiyoshi, Yoshizawa Tohru, Matsumoto Hiroyuki(1975) Vitamin to Hokouso (eds Nihon Seikagakukai) Chapter.14 Vitamin A pp.549 Tokyo Kagaku Dojin |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | R.Marbet, Ger. pat. 1971, 2,061,507 (to Hoffmann-La Roche) |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | R.Marbet, U.S. pat. 1973, 3,746,730 (to Hoffmann-La Roche) |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Landthaler, M., Kummermehr, J., Wagner, A., and Plewig, G. |
TITLE | : | Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands PubMed ID:6453562 |
JOURNAL | : | Arch Dermatol Res. |
VOL | : | 269 PAGE : 297-309 (1980) |
AUTHOR | : | Guy, R., Ridden, C., and Kealey, T. |
TITLE | : | The improved organ maintenance of the human sebaceous gland: modeling in vitro the effects of epidermal growth factor, androgens, estrogens, 13-cis retinoic acid, and phenol red PubMed ID:8648176 |
JOURNAL | : | J Invest Dermatol. |
VOL | : | 106 PAGE : 454-460 (1996) |
AUTHOR | : | Seikagaku Hand Book (eds. Nihon Seikagakukai) pp.1274-1277. Tokyo Kagaku Dojin |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |