Back to HOME

Vitamin D


DATA No : VVD0001 INFORMANT : Sachiko Yamada

NAME : (7E)-(1R,3R)-1,3-dihydroxy-19-nor-9,10-seco-5,7-pregnadien-20-one

COMMON NAME: 1a-hydroxy-20-oxo-19,22,23,24,25,26,27-heptanorvitamin D3 / 1a-hydroxy-20-oxo-19,22,23,24,25,26,27-heptanorcholecalciferol
SYMBOL: 1a-OH-20-oxo-19,22,23,24,25,26,27-heptanor-D3
FORMULA: C20H30O3 MOL.WT (average) : 318.450


Download ChemDraw structure data
BIOLOGICAL ACTIVITY
Had no affinity for progesterone receptor in MCF-7. (Ref. 0304)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:lmax (EtOH) (nm) 243, 251.5, 261 (Ref. 0304)

IR SPECTRA:

NMR SPECTRA:1H-NMR (d, CDCl3) 0.51 (3H, s, 18-CH3), 2.14 (3H, s, 21-CH3), 4.06 (1H, m, 3a-H), 4.13 (1H, m, 1b-H), 5.88 (1H, d, J = 11.3 Hz, 7-H), 6.29 (1H, d, J = 11.3 Hz, 6-H) (Ref. 0304)

MASS SPECTRA:m/z 318 (M+, 85), 300 (5), 282 (2), 275 (35) 239 (41), 133 (100), 95 (100) (Ref. 0304)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS
From corresponding C-22 aldehyde via oxidative decarbonylation. (Ref. 0304)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0304]
AUTHOR:Perlman, K. L.; Darwish, H. M.; DeLuca, H. F.
TITLE:20-Oxopregnacalciferols : Vitamin D Compounds That Bind The Progesterone Receptor.
JOURNAL:Tetrahedron Lett.
VOL:35 PAGE : 2295 -2298 (1994)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.