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Vitamin D


DATA No : VVD0008 INFORMANT : Sachiko Yamada

NAME : (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-seco-23,24-dinor-5,7,10(19)-cholatrien-22-one

COMMON NAME: 1a-hydroxy-22-oxo-23,24,25,26,27-pentanorvitamin D3 / 1a-hydroxy-22-oxo-23,24,25,26,27-pentanorcholecalciferol
SYMBOL: 1a-OH-22-oxo-pentanor-D3
FORMULA: C22H32O3 MOL.WT (average) : 344.488


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BIOLOGICAL ACTIVITY
HL-60 human promyelocytes differentiation: ED50 in nitro blue tetrazplium reduction, phagocytic activity, and nonspecific acid esterase activity are 7.5 times 10-7 M, 8.2 times 10-7 M and 8.5 times 10-7 M, respectively, when 1,25-(OH)2D3 shows the respective ED50 values of 1.0 times 10-8 M, 1.0 times 10-8 M and 1.1 times 10-8 M, respectively. (Ref. 0228)
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CHEMICAL SYNTHESIS
From C(22) ester precursor. (Ref. 0228)
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REFERENCES
[0228]
AUTHOR:Ostrem, V. K., Lau, W. F., Lee, S. H., Perlman, K., Prahl, J., Schnoes, H. K., and DeLuca, H. F.
TITLE:Induction of monocytic differentiation of HL-60 cells by 1,25-dihydroxyvitamin D analogs PubMed ID:3477545
JOURNAL:J Biol Chem.
VOL:262 PAGE : 14164-14171 (1987)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.