Vitamin D

DATA No : VVD0015 INFORMANT : Sachiko Yamada

NAME : (5Z,7E)-(1S,3R)-24-nor-9,10-seco-5,7,10(19)-cholatriene-1,3-diol

COMMON NAME	:	1a-hydroxy-24,25,26,27-tetranorvitamin D₃ / 1a-hydroxy-24,25,26,27-tetranorcholecalciferol
SYMBOL	:	1a-OH-23,24,25,26,27-tetranor-D₃
FORMULA	:	C₂₃H₃₆O₂ MOL.WT (average) : 344.531

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BIOLOGICAL ACTIVITY

HL-60 human promyelocytes differentiation : ED50 in nitro blue tetrazolium reduction, phagocytic activity, and nonspecific acid esterase activity are 2.3

10^-⁷ M, 2.5

10^-⁷ M and 2.7

10^-⁷ M, respectively, when 1,25-(OH)₂D₃ shows the respective ED50 values of 1.0

10^-⁸ M, 1.0

10^-⁸ M and 1.1

10^-⁸ M, respectively. (Ref. 0228)

PHYSICAL AND CHEMICAL PROPERTIES

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CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

Prepared via 3,5-cyclovitamin D intermediate. (Ref. 0228)

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[0228]

AUTHOR	:	Ostrem, V. K., Lau, W. F., Lee, S. H., Perlman, K., Prahl, J., Schnoes, H. K., and DeLuca, H. F.
TITLE	:	Induction of monocytic differentiation of HL-60 cells by 1,25-dihydroxyvitamin D analogs PubMed ID:3477545
JOURNAL	:	J Biol Chem.
VOL	:	262 PAGE : 14164-14171 (1987)

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