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Vitamin D


DATA No : VVD0018 INFORMANT : Sachiko Yamada

NAME : (5E,7E)-(3S,22R)- 24-nor-9,10-seco-5,7,10(19)-cholatriene-3,22-diol

COMMON NAME: (5E)-(22R)-22-hydroxy-24,25,26,27-tetranorvitmin D3 / (5E)-(22R)-22-hydroxy-24,25,26,27-tetranorcholecalciferol
SYMBOL: (5E)-22R-OH-24,25,26,27-tetranor-D3
FORMULA: C23H36O2 MOL.WT (average) : 344.531


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:1H-NMR (d, CDCl3, 270MHz) 0.59 (3H, s, 18-H), 0.93 (3H, d, J = 6.6 Hz, 21-H), 1.04 (3H, d, J = 6.3 Hz, 23-H), 3.89 (1H, m, 3-H), 3.93 (1H, m, 22-H), 4.69 and 4.98 (each 1H, s, 19-H), 5.88 and 6.54 (each 1H, d, J = 11.6 Hz, 6- and 7-H) (Ref. 0334)

MASS SPECTRA:m/z 344 (M+, 63.4), 326 (100), 308 (23.1), 271 (14.2), 253 (40.0), 251 (37.5) (Ref. 0334)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS
From vitamin D2 sulfur dioxide adduct via ozonolysis followed by Grignard reaction. (Ref. 0334)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0334]
AUTHOR:Shimizu, M.; Iwasaki, Y.; Ishida, H.; Yamada, S.
TITLE:Determination of 25-Hydroxyvitamin D3 in Human Plasma Using a Non-radioactive Tetranorvitamin D Analogue as an Internal Standard. PubMed ID:8590938
JOURNAL:J. Chromat. B
VOL:672 PAGE : 63 -71 (1995)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.