Vitamin D

DATA No : VVD0019 INFORMANT : Sachiko Yamada

NAME : (5E,7E)-(3S,22S)- 24-nor-9,10-seco-5,7,10(19)-cholatriene-3,22-diol

COMMON NAME	:	(5E)-(22S)-22-hydroxy-24,25,26,27-tetranorvitmin D₃ / (5E)-(22S)-22-hydroxy-24,25,26,27-tetranorcholecalciferol
SYMBOL	:	(5E)-22S-OH-24,25,26,27-tetranor-D₃
FORMULA	:	C₂₃H₃₆O₂ MOL.WT (average) : 344.531

BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES

SPECTRAL DATA

UV SPECTRA	:

IR SPECTRA	:

NMR SPECTRA	:	¹H-NMR (d, CDCl₃, 270MHz) 0.57 (3H, s, 18-H), 0.93 (3H, d, J = 6.8 Hz, 21-H), 1.17 (3H, d, J = 6.4 Hz, 23-H), 3.89 (1H, m, 3-H), 3.97 (1H, dq, J = 6.4 and 1.4 Hz, 22-H), 4.69 and 4.98 (each 1H, s, 19-H), 5.88 and 6.55 (each 1H, d, J = 11.6 Hz, 6- and 7-H) (Ref. 0334)

MASS SPECTRA	:	m/z 344 (M⁺, 63.4), 326 (100), 308 (23.1), 271 (14.2), 253 (40.0), 251 (37.5) (Ref. 0334)

OTHER SPECTRA	:

CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

From vitamin D₂ sulfur dioxide adduct via ozonolysis followed by Grignard reaction. (Ref. 0334)

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[0334]

AUTHOR	:	Shimizu, M.; Iwasaki, Y.; Ishida, H.; Yamada, S.
TITLE	:	Determination of 25-Hydroxyvitamin D₃ in Human Plasma Using a Non-radioactive Tetranorvitamin D Analogue as an Internal Standard. PubMed ID:8590938
JOURNAL	:	J. Chromat. B
VOL	:	672 PAGE : 63 -71 (1995)