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Vitamin E


DATA No : VVE0005 INFORMANT : Fumiko Hirahara

NAME : 2R-(4R',8R',12'-trimethyltridecyl)-2,5,8-trimethylchroman-6-ol

COMMON NAME: b-tocopherol
SYMBOL: b-Toc
FORMULA: C28H48O2 MOL.WT (average) : 416.680


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BIOLOGICAL ACTIVITY
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. RRR-b-tocopherol has been reported as 25-40% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test.
[Table 0008] RRR-b-tocopherol has been assigned an activity of 0.5 mg a-TE per milligram.
[Table 0010] (Ref. 0034/0035/0036)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:200-210deg(Ref. 0009)

REFRACTIVE INDEX:

OPTICAL ROTATION:a5461-25.gif" HEIGHT="16" WIDTH="22" ALT="546.1-25">=+2.9(ethanol),+0.9(benzene)deg(Ref. 0001)/dd-20=+6.37deg(Ref. 0009)

DENSITY:

SOLUBILITY:Freely soluble in oils, fats, acetone, alcohol, chlororoform, ether, other fat solvents.(Ref. 0009)
SPECTRAL DATA
UV SPECTRA:296nm, E1%1cm=89.4(ethanol)(Ref. 0001)

IR SPECTRA:3320,2940,1595,1458,1373,1229,1158,860cm-1

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E.
[Chromatogram 0005] (Ref. 0038)
SOURCE
1.Wheat germ 2.Sencha Tea 3.Rice bran oil 4.Mixed vegetable oil 5.High linoleic acid type margarine(Ref. 0003/0005/0006/0033/0034)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0001]
AUTHOR:Kasparek,S.(1980)Chemistry of Tocopherols and Tocotrienols, in Vitamin E, a comprehensive Treasure (Machlin, L.J. ,eds.), PP7-65, Marcel Dekker, INC., New York and Basel
TITLE:
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[0003]
AUTHOR:Standard Tables of Fat-soluble Food Composition in Japan (1995) Fatty Acid,Cholesterol,Vitamin E( the Science and Technology Agency,eds),,pp13-103, Ishiyaku Press Ltd. (Japan),Tokyo
TITLE:
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[0005]
AUTHOR:Goh S. H. , Choo, Y. M. and Ong, S. H.
TITLE:
JOURNAL:J. Amer. Oil Chem. Soc.
VOL:62 PAGE : 237 -240 (1985)
[TOP]

[0006]
AUTHOR:Leth, T., and Sondergaard, H.
TITLE:Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds PubMed ID:925769
JOURNAL:J Nutr.
VOL:107 PAGE : 2236-2243 (1977)
[TOP]

[0009]
AUTHOR:Tocopherol(1996), in The Merck Index (Twelfth Edition), pp1620, Merck & Co., Inc.
TITLE:
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[0033]
AUTHOR:Ong,A.S.H.(1993) Natural Sources of Tocotrienols, in Vitamin E in Health and Disease (Packer,L. and Fuchs,J. eds) ,pp3-8,Marcel Dekke,Inc., New York,Basel,Hong Kong
TITLE:
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[0034]
AUTHOR:Kijima,S. (1993) Chemistry of Vitamin E, in Vitamin E, Its Usefulness in Health and in Curing Disease (Mino,M., Nakmura,H., Diplock,A. and Kayden,H.J. eds),pp3-11,Japan Scientific Societies Press
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[0035]
AUTHOR:Burton, G. W., Traber, M. G., Acuff, R. V., Walters, D. N., Kayden, H., Hughes, L., and Ingold, K. U.
TITLE:Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E PubMed ID:9537614
JOURNAL:Am J Clin Nutr.
VOL:67 PAGE : 669-684 (1998)
[TOP]

[0036]
AUTHOR:Sheppard,A.J., Pennington,A.T. and Weihrauch,J.L.(1993) Analysis and Distribution of Vitamin E in Vegetable Oils and Foods in Vitamin E in Health and Disease (Packer,L. and Fuchs,J. eds) ,pp9-31,Marcel Dekke,Inc., New York,Basel,Hong Kong
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[0038]
AUTHOR:Abe,K. and Matsumoto,A.(1993) Quantitative Determination of Tocopherols, Its Usefulness in Health and in Curing Disease (Mino,M., Nakmura,H., Diplock,A. and Kayden,H.J. eds),pp13-19,Japan Scientific Societies Press
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