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Vitamin E


DATA No : VVE0019 INFORMANT : Fumiko Hirahara

NAME : 2-(4',8',12'-trimethyltrideca-3',7',11'-trienyl)-2,5,8-trimethylchroman-6-ol

COMMON NAME: b-tocotrienol
SYMBOL: b-T3
FORMULA: C28H42O2 MOL.WT (average) : 410.632


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BIOLOGICAL ACTIVITY
The true biological activity of vitamin E is determined by its ability to prevent or reverse specific vitamin E deficiency symptoms in animal in vivo (e.g., fatal resorption, muscular dystrophy, and encephlomalacia). Other tests, such as the erythrocyte hemolysis test and elevation of plasma tocopherol, have been used. all-trans-b-tocotrienol has been reported as 5% of RRR-a-tocopherol when evaluated by the rat resorption-gestation test.
[Table 0008] all-trans-b-tocotrienol has been assigned an activity of 0.05 mg a-TE per milligram.
[Table 0010] (Ref. 0034/0035/0036)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:230degC(bath)/0.05mm

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:295 nm, E1%1cm=85.0(ethanol)

IR SPECTRA:3370,1592,1439,1404,1370,1220,1153,1091,1053,997,847 and 691 cm-1

NMR SPECTRA:1H-NMR: 6.45,5.12,4.38,2.62,2.08-1.62,1.25 ppm NMR Spectrum of b-Tocotrienol(60 MHz:CDCl3)
[Spectrum 0001] (Ref. 0032)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA
Many analytical methods (colorimetric, fluorometric,TLC,GC,HPLC) have been reported for the determination of Tocopherols and tocotrienols. At the present time, HPLC methods are popular for the analysis of vitamin E.
[Chromatogram 0005] (Ref. 0038)
SOURCE
1.Barley 2.Wheat Germ (Ref. 0034)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0032]
AUTHOR:Katui,G.(1980) Chemistry of Vitamin E and Its Related Compounds, in Vitaminology [1], Fat-soluble Vitamins (Japanese Vitamin Society eds.), pp183-193, Tokyo Kagaku Dojin,Tokyo
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[0034]
AUTHOR:Kijima,S. (1993) Chemistry of Vitamin E, in Vitamin E, Its Usefulness in Health and in Curing Disease (Mino,M., Nakmura,H., Diplock,A. and Kayden,H.J. eds),pp3-11,Japan Scientific Societies Press
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[0035]
AUTHOR:Burton, G. W., Traber, M. G., Acuff, R. V., Walters, D. N., Kayden, H., Hughes, L., and Ingold, K. U.
TITLE:Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E PubMed ID:9537614
JOURNAL:Am J Clin Nutr.
VOL:67 PAGE : 669-684 (1998)
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[0036]
AUTHOR:Sheppard,A.J., Pennington,A.T. and Weihrauch,J.L.(1993) Analysis and Distribution of Vitamin E in Vegetable Oils and Foods in Vitamin E in Health and Disease (Packer,L. and Fuchs,J. eds) ,pp9-31,Marcel Dekke,Inc., New York,Basel,Hong Kong
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[0038]
AUTHOR:Abe,K. and Matsumoto,A.(1993) Quantitative Determination of Tocopherols, Its Usefulness in Health and in Curing Disease (Mino,M., Nakmura,H., Diplock,A. and Kayden,H.J. eds),pp13-19,Japan Scientific Societies Press
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.