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Eicosanoid


DATA No : XPR1100 INFORMANT : Shouzo Yamamoto

NAME : 7-[2-(3(S)-Hydroxy-1(E)-octenyl)-5-oxo-1-cyclopenten-1-yl]heptanoic acid / (E,S)-15-Hydroxy-9-oxo-8(12),13-prostadienoic acid

COMMON NAME: PROSTAGLANDIN B1
SYMBOL: PGB1
FORMULA: C20H32O4 MOL.WT (average) : 336.466


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:70-71degC (Ref. 1102)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:l max = 278nm(e 28,650) (Ref. 1103)

IR SPECTRA:5.91, 6.10, 6.27, 10.3mm (Ref. 1104)

NMR SPECTRA:1H-NMR :d 6.87(d, J=16Hz, 1H, 13-CH), 6.25(d,d, J=16.6Hz, 1H, 14-CH), 4.38(1H, 15-CH) (Ref. 1105)

MASS SPECTRA:METHYL ESTER ; m/e 350(M+), 332, 319, 301, 251, 219 (Ref. 1106)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Prostaglandin B1 is found in human seminal plasma (Ref. 0001).
CHEMICAL SYNTHESIS
(Ref. 1105)
[Table 0001]
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0001]
AUTHOR:Bergstrom, S.
TITLE:Prostaglandins: members of a new hormonal system. These physiologically very potent compounds of ubiquitous occurrence are formed from essential fatty acids PubMed ID:4291104
JOURNAL:Science.
VOL:157 PAGE : 382-391 (1967)
[TOP]

[1102]
AUTHOR:Ramwell,P.W., Shaw,J.E., Clarke,G.B., Grostic,M.F., Kaiser,D.G. and Pike, J.E.
TITLE:Prostaglandins (Review).
JOURNAL:Progr. Chem. Fats Other Lipids
VOL:9 PAGE : 233 -273 (1968)
[TOP]

[1103]
AUTHOR:Jones, R. L.
TITLE:15-hydroxy-9-oxoprosta-11, 13-dienoic acid as the product of a prostaglandin isomerase PubMed ID:5064903
JOURNAL:J Lipid Res.
VOL:13 PAGE : 511-518 (1972)
[TOP]

[1104]
AUTHOR:Hamberg, M., and Samuelsson, B.
TITLE:Prostaglandins in human seminal plasma. Prostaglandins and related factors 46 PubMed ID:5903721
JOURNAL:J Biol Chem.
VOL:241 PAGE : 257-263 (1966)
[TOP]

[1105]
AUTHOR:Collins, P., Jung, C. J., and Pappo, R.
TITLE:Prostaglandin studies: the total synthesis of DL-prostaglandin B1 PubMed ID:12310168
JOURNAL:Isr J Chem.
VOL:6 PAGE : 839-841 (1968)
[TOP]

[1106]
AUTHOR:Struijk,M.C.B., Beerthuis,R.K., Pabon,H.J.J. and Van Dorp,D.A.
TITLE:Specificity in the Enzymic Conversion of Polyunsaturated Fatty Acids into Prostaglandins.
JOURNAL:Recueil
VOL:85 PAGE : 1233 -1250 (1966)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.