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Eicosanoid


DATA No : XPR1131 INFORMANT : Shouzo Yamamoto

NAME : 7-[2-(3(S),7-Dihydroxy-1(E)-octenyl)-5-oxo-1-cyclopenten-1-yl]-5(Z)-heptenoic acid / 15(S),19-Dihydroxy-9-oxo-5-cis-8(12),13-trans-prostatrienoic acid

COMMON NAME: 19-HYDROXY-PROSTAGLANDIN B2
SYMBOL: 19-HYDROXY-PGB2
FORMULA: C20H30O5 MOL.WT (average) : 350.449


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BIOLOGICAL ACTIVITY
19-Hydroxy-prostaglandin B2 relaxes uterine myometriuim (Ref. 0082).
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:ETHANOL (Ref. 1104)
SPECTRAL DATA
UV SPECTRA:l EtOHmax = 278 nm(e sim20,000) (Ref. 1104)

IR SPECTRA: 5.92, 6.09, 6.26, 10.3mm (Ref. 1104)

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
The compound is contained in human seminal plasma in a considerable amount (Ref. 0001), but it is attributed presumably to a degradation product of 19-hydroxy-prostagaldnin E2 (Ref. 0094).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0001]
AUTHOR:Bergstrom, S.
TITLE:Prostaglandins: members of a new hormonal system. These physiologically very potent compounds of ubiquitous occurrence are formed from essential fatty acids PubMed ID:4291104
JOURNAL:Science.
VOL:157 PAGE : 382-391 (1967)
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[0082]
AUTHOR:Horton, E. W.
TITLE:Hypotheses on physiological roles of prostaglandins PubMed ID:4302663
JOURNAL:Physiol Rev.
VOL:49 PAGE : 122-161 (1969)
[TOP]

[0094]
AUTHOR:Taylor, P. L., and Kelly, R. W.
TITLE:19-Hydroxylated E prostaglandins as the major prostaglandins of human semen PubMed ID:4855446
JOURNAL:Nature.
VOL:250 PAGE : 665-667 (1974)
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[1104]
AUTHOR:Hamberg, M., and Samuelsson, B.
TITLE:Prostaglandins in human seminal plasma. Prostaglandins and related factors 46 PubMed ID:5903721
JOURNAL:J Biol Chem.
VOL:241 PAGE : 257-263 (1966)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.