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Eicosanoid


DATA No : XPR1421 INFORMANT : Shouzo Yamamoto

NAME : 8-[2(R)-(2-Carboxyethyl)-5(R)-hydroxy-3-oxocyclopentan-1(R)-yl]-6-oxooctanoic acid

COMMON NAME: PROSTAGLANDIN E-MAJOR URINARY METABOLITE
SYMBOL: PGE-MUM
FORMULA: C16H24O7 MOL.WT (average) : 328.358


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:ETHYL ACETATE (Ref. 1061)
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:DIMETHYL ESTER DI-O-METHYLOXIME TMS ETHER DERIVATIVE ; m/e 486, 455, 369, 365, 355, 286, 279, 268, 265, 196, 115 (Ref. 1061)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
When prostaglandin E2 or E1 was administered intravenously to man, 7a-hydroxy-5,11-diketo-tetranor-prosta-1,16-dioic acid was found as a major urinary metabolite (PGE-MUM) (Ref. 0045).
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0045]
AUTHOR:Hamberg,M., and Samuelsson,B.
TITLE:On the metabolism of prostaglandin E1 and E2 in man. PubMed ID:5126221
JOURNAL:J. Biol. Chem.
VOL:246 PAGE : 6713 -6721 (1971)
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[1061]
AUTHOR:Hamberg, M., and Samuelsson, B.
TITLE:The structure of the major urinary metabolite of prostaglandin E2 in man PubMed ID:5784182
JOURNAL:J Am Chem Soc.
VOL:91 PAGE : 2177-2178 (1969)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.